Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice

•Chronic stress decreases hippocampal NGF but not cytokine and BDNF mRNA levels.•Roman chamomile with clomipramine decreases immobility time in a forced swim test.•Roman chamomile with clomipramine decreases serum corticosterone levels.•Roman chamomile with clomipramine increases hippocampal neuroge...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 118; p. 109263
Main Authors:	Hashikawa-Hobara, Narumi, Otsuka, Ami, Ishikawa, Risa, Hashikawa, Naoya
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-10-2019 Elsevier
Subjects:	Animals Behavior, Animal Cell Proliferation - drug effects Chamaemelum - chemistry Chamomile Chronic stress Clomipramine - pharmacology Clomipramine - therapeutic use Corticosterone Corticosterone - blood Cytokines - genetics Cytokines - metabolism Depression - blood Depression - drug therapy Drug Therapy, Combination Hippocampus - drug effects Hippocampus - metabolism Inhalation Exposure Male Mice Mice, Inbred C57BL Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Neurogenesis - drug effects Plant Extracts - pharmacology Plant Extracts - therapeutic use RNA, Messenger - genetics RNA, Messenger - metabolism Stress, Psychological - blood Stress, Psychological - drug therapy Treatment-resistant depression Chronic stress IL BDNF Corticosterone RT-PCR Treatment-resistant depression DCX Mice NGF Chamomile TNF
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