Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects

• Published in: Biomedicine & pharmacotherapy Vol. 157; p. 113978
• Main Authors: Ye, Xun, Li, Jinhu, Liu, Zibo, Sun, Xue, Wei, Daneng, Song, Linjiang, Wu, Chunjie
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-01-2023; Elsevier
• Subjects: Extracellular matrix components; Fibrosis; Humans; Inflammation; Liver Cirrhosis - metabolism; Myofibroblasts; Peptide; TGF-β; Transforming Growth Factor beta - metabolism; GLP-1; DMN; CNP; BNP; Extracellular matrix components; Inflammation; EMT; ECM; Fibrosis; TGF-β; VNP; HSCs; VDAC1; Peptide; EndMT
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2022.113978

Fibrosis, a disease characterized by an excess accumulation of extracellular matrix components, could lead to organ failure and death, and is to blame for up to 45 % of all fatalities in developed nations. These disorders all share the common trait of an unchecked and increasing accumulation of fibrotic tissue in the affected organs, which leads to their malfunction and eventual failure, even if their underlying causes are highly diverse and, in some cases, remain unclear. Numerous studies have identified activated myofibroblasts as the common cellular elements ultimately responsible for the replacement of normal tissues with nonfunctional fibrotic tissue. The transforming growth factor-β pathway, for instance, plays a significant role in practically all kinds of fibrosis. However, there is no specific drug for the treatment of fibrosis, several medications with anti-hepatic fibrosis properties are still in the research and development stages. Peptide, which refers to a substance consisting of 2–50 amino acids, is characterized by structural diversity, low toxicity, biological activities, easy absorption, specific targeting, few side effects, and has been proven to be effective in anti-fibrosis. Here, we summarized various anti-fibrosis peptides in fibrosis including the liver, lungs, kidneys, and other organs. This review will provide a new insight into peptide mediated anti-fibrosis and is helpful to creation of antifibrotic medications.
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•We summarize the pharmacological effects and mechanisms of peptide on fibrosis diseases.•Peptide can regulate the generation and degradation of extracellular matrix to inhibit or slow down the process of fibrotic diseases.•Peptide drugs are promising theraputic approachs for the treatment of fibrotic diseases.