Trafficking and Cell Surface Stability of the Epithelial Na+ Channel Expressed in Epithelial Madin-Darby Canine Kidney Cells

The apically located epithelial Na+ channel (αβγ-ENaC) plays a key role in the regulation of salt and fluid transport in the kidney and other epithelia, yet its mode of trafficking to the plasma membrane and its cell surface stability in mammalian cells are poorly understood. Because the expression...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 277; no. 12; pp. 9772 - 9779
Main Authors:	Hanwell, David, Ishikawa, Toru, Saleki, Reza, Rotin, Daniela
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 22-03-2002 American Society for Biochemistry and Molecular Biology
Subjects:	Animals Biotinylation Cell Line Cell Membrane - metabolism Detergents - pharmacology Dogs Dose-Response Relationship, Drug Electrophysiology Epithelial Cells Epithelial Sodium Channels Epitopes Glycoside Hydrolases - metabolism Glycosylation Immunoblotting Lipids - chemistry Membrane Microdomains - metabolism Microscopy, Electron Microscopy, Immunoelectron Octoxynol - pharmacology Patch-Clamp Techniques Protein Structure, Tertiary Rats Sodium Channels - metabolism Time Factors Xenopus
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