Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner

The immune microenvironment in breast cancer (BCa) is controlled by a complex network of communication between various cell types. Here, we find that recruitment of B lymphocytes to BCa tissues is controlled via mechanisms associated with cancer cell-derived extracellular vesicles (CCD-EVs). Gene ex...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 42; no. 3; p. 112207
Main Authors:	Molostvov, Guerman, Gachechiladze, Mariam, Shaaban, Abeer M., Hayward, Steven, Dean, Isaac, Dias, Irundika H.K., Badr, Nahla, Danial, Irini, Mohammed, Fiyaz, Novitskaya, Vera, Paniushkina, Liliia, Speirs, Valerie, Hanby, Andrew, Nazarenko, Irina, Withers, David R., van Laere, Steven, Long, Heather M., Berditchevski, Fedor
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 28-03-2023 Elsevier
Subjects:	B cells B-Lymphocytes - metabolism breast cancer Breast Neoplasms - genetics CP: Cancer Female Humans Liver X Receptors - metabolism LXR oxysterols Oxysterols - pharmacology Tetraspanins Tumor Microenvironment tetraspanins oxysterols CP: Cancer LXR breast cancer B cells tumor microenvironment
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