Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin
Abstract Objective. To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy. Methods. We retrospectively evaluated the clinical course and outcome of 34 children with acute necrotizing encephalopathy. They were divided i...
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| Published in: | Brain & development (Tokyo. 1979) Vol. 31; no. 3; pp. 221 - 227 |
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| Language: | English |
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Elsevier B.V
01-03-2009
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| Abstract | Abstract Objective. To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy. Methods. We retrospectively evaluated the clinical course and outcome of 34 children with acute necrotizing encephalopathy. They were divided into two groups; 17 patients with brainstem lesion and 17 patients without brainstem lesion. Early steroid use was defined as when steroids were administered within 24 h after the onset. The outcome was judged as good when a patient had no or mild cognitive impairment and poor when a patient had more severe sequelae, or died. Results. Among patients without brainstem lesions, the outcome was good in 7 of 12 with early steroid, whereas it was poor in all 5 patients without early steroid. There was no significant difference in sex, age, and laboratory data between patients with and without early steroid. The outcome was not correlated with gammaglobulin treatment. As to patients without brainstem lesions, the outcome was not correlated with early steroid or gammaglobulin treatment. Conclusions. Steroid within 24 h after the onset was related to better outcome of children with acute necrotizing encephalopathy without brainstem lesions. Early steroid treatment will be an important option of the treatment for acute necrotizing encephalopathy. |
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| AbstractList | Objective. To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy.
Methods. We retrospectively evaluated the clinical course and outcome of 34 children with acute necrotizing encephalopathy. They were divided into two groups; 17 patients with brainstem lesion and 17 patients without brainstem lesion. Early steroid use was defined as when steroids were administered within 24
h after the onset. The outcome was judged as good when a patient had no or mild cognitive impairment and poor when a patient had more severe sequelae, or died.
Results. Among patients without brainstem lesions, the outcome was good in 7 of 12 with early steroid, whereas it was poor in all 5 patients without early steroid. There was no significant difference in sex, age, and laboratory data between patients with and without early steroid. The outcome was not correlated with gammaglobulin treatment. As to patients without brainstem lesions, the outcome was not correlated with early steroid or gammaglobulin treatment.
Conclusions. Steroid within 24
h after the onset was related to better outcome of children with acute necrotizing encephalopathy without brainstem lesions. Early steroid treatment will be an important option of the treatment for acute necrotizing encephalopathy. OBJECTIVETo examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy.METHODSWe retrospectively evaluated the clinical course and outcome of 34 children with acute necrotizing encephalopathy. They were divided into two groups; 17 patients with brainstem lesion and 17 patients without brainstem lesion. Early steroid use was defined as when steroids were administered within 24h after the onset. The outcome was judged as good when a patient had no or mild cognitive impairment and poor when a patient had more severe sequelae, or died.RESULTSAmong patients without brainstem lesions, the outcome was good in 7 of 12 with early steroid, whereas it was poor in all 5 patients without early steroid. There was no significant difference in sex, age, and laboratory data between patients with and without early steroid. The outcome was not correlated with gammaglobulin treatment. As to patients without brainstem lesions, the outcome was not correlated with early steroid or gammaglobulin treatment.CONCLUSIONSSteroid within 24 h after the onset was related to better outcome of children with acute necrotizing encephalopathy without brainstem lesions. Early steroid treatment will be an important option of the treatment for acute necrotizing encephalopathy. To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy. We retrospectively evaluated the clinical course and outcome of 34 children with acute necrotizing encephalopathy. They were divided into two groups; 17 patients with brainstem lesion and 17 patients without brainstem lesion. Early steroid use was defined as when steroids were administered within 24h after the onset. The outcome was judged as good when a patient had no or mild cognitive impairment and poor when a patient had more severe sequelae, or died. Among patients without brainstem lesions, the outcome was good in 7 of 12 with early steroid, whereas it was poor in all 5 patients without early steroid. There was no significant difference in sex, age, and laboratory data between patients with and without early steroid. The outcome was not correlated with gammaglobulin treatment. As to patients without brainstem lesions, the outcome was not correlated with early steroid or gammaglobulin treatment. Steroid within 24 h after the onset was related to better outcome of children with acute necrotizing encephalopathy without brainstem lesions. Early steroid treatment will be an important option of the treatment for acute necrotizing encephalopathy. Abstract Objective. To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy. Methods. We retrospectively evaluated the clinical course and outcome of 34 children with acute necrotizing encephalopathy. They were divided into two groups; 17 patients with brainstem lesion and 17 patients without brainstem lesion. Early steroid use was defined as when steroids were administered within 24 h after the onset. The outcome was judged as good when a patient had no or mild cognitive impairment and poor when a patient had more severe sequelae, or died. Results. Among patients without brainstem lesions, the outcome was good in 7 of 12 with early steroid, whereas it was poor in all 5 patients without early steroid. There was no significant difference in sex, age, and laboratory data between patients with and without early steroid. The outcome was not correlated with gammaglobulin treatment. As to patients without brainstem lesions, the outcome was not correlated with early steroid or gammaglobulin treatment. Conclusions. Steroid within 24 h after the onset was related to better outcome of children with acute necrotizing encephalopathy without brainstem lesions. Early steroid treatment will be an important option of the treatment for acute necrotizing encephalopathy. |
| Author | Imataka, George Okumura, Akihisa Hosoya, Mitsuaki Kidokoro, Hiroyuki Noda, Eiko Kurahashi, Hirokazu Abe, Sinpei Yamamoto, Hitoshi Tanaka, Manabu Tanabe, Takuya Aiba, Hideo Maegaki, Yoshihiro Mizuguchi, Masashi |
| Author_xml | – sequence: 1 fullname: Okumura, Akihisa – sequence: 2 fullname: Mizuguchi, Masashi – sequence: 3 fullname: Kidokoro, Hiroyuki – sequence: 4 fullname: Tanaka, Manabu – sequence: 5 fullname: Abe, Sinpei – sequence: 6 fullname: Hosoya, Mitsuaki – sequence: 7 fullname: Aiba, Hideo – sequence: 8 fullname: Maegaki, Yoshihiro – sequence: 9 fullname: Yamamoto, Hitoshi – sequence: 10 fullname: Tanabe, Takuya – sequence: 11 fullname: Noda, Eiko – sequence: 12 fullname: Imataka, George – sequence: 13 fullname: Kurahashi, Hirokazu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18456443$$D View this record in MEDLINE/PubMed |
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| Snippet | Abstract Objective. To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy.... Objective. To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy. Methods. We... To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy. We retrospectively... OBJECTIVETo examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy.METHODSWe... |
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| SubjectTerms | Acute necrotizing encephalopathy Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - adverse effects Adrenal Cortex Hormones - therapeutic use Brain Diseases - drug therapy Brain Diseases - mortality Brain Diseases - pathology Brain Stem - drug effects Brain Stem - immunology Brain Stem - pathology Brainstem lesion Child Child, Preschool Cognition Disorders Female gamma-Globulins - therapeutic use Humans Infant Male Necrosis Neurology Outcome Retrospective Studies Sex Characteristics Steroid Treatment Outcome |
| Title | Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin |
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