Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth

Abstract Aim of the study Metabolic adaptations are essential during tumour growth to maintain the high proliferation levels exhibited by cancer cells. In this study, we examined the transformations that occurred in the lipid metabolism in astrocytic tumours, and the possible role of the fuel-sensin...

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Bibliographic Details
Published in:	European journal of cancer (1990) Vol. 50; no. 18; pp. 3187 - 3197
Main Authors:	Ríos, M, Foretz, M, Viollet, B, Prieto, A, Fraga, M, García-Caballero, T, Costoya, J.A, Señarís, R
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01-12-2014 Elsevier
Subjects:	AMP-Activated Protein Kinases - metabolism AMPK Animals Astrocytes - enzymology Astrocytes - pathology Biological and medical sciences Brain Neoplasms - enzymology Brain Neoplasms - pathology Cell Proliferation - physiology Fatty Acids - biosynthesis Glioblastoma - enzymology Glioblastoma - pathology Glioma Hematology, Oncology and Palliative Medicine Humans Lipid metabolism Lipid Metabolism - physiology Lipoprotein receptors Medical sciences Mice, Knockout Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments PTEN Phosphohydrolase - antagonists & inhibitors Receptors, Lipoprotein - antagonists & inhibitors Receptors, Lipoprotein - metabolism Transfection Tumor Cells, Cultured Tumors AMPK Lipid metabolism Glioma Lipoprotein receptors Cell proliferation Nervous system diseases Glioblastoma Lipids Activation Malignant tumor Lipoprotein Metabolism cAMP-dependent protein kinase Carcinogenesis Malignant glioma Cancerology Central nervous system disease Cancer Biological receptor
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