Prostate-specific antigen testing after the US Preventive Services Task Force recommendation: a population-based analysis of electronic health data

• Published in: Cancer causes & control Vol. 31; no. 9; pp. 861 - 867
• Main Authors: Frendl, Daniel M., Epstein, Mara M., Fouayzi, Hassan, Krajenta, Richard, Rybicki, Benjamin A., Sokoloff, Mitchell H.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-09-2020; Springer Nature B.V
• Subjects: Adult; Advisory Committees; Age; Age Factors; Aged; Aged, 80 and over; Antigens; Biomedical and Life Sciences; Biomedicine; Brief Report; Cancer Research; Early Detection of Cancer - statistics & numerical data; Electronic Health Records - statistics & numerical data; Epidemiology; Guideline Adherence; Health care; Hematology; Humans; Kallikreins - analysis; Longitudinal Studies; Male; Massachusetts - epidemiology; Michigan - epidemiology; Middle Aged; Oncology; Preventive Health Services - statistics & numerical data; Prostate; Prostate cancer; Prostate-specific antigen; Prostate-Specific Antigen - analysis; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - epidemiology; Public Health; Regression Analysis; Task forces; Trends; United States - epidemiology; United States; Massachusetts; Michigan; United States > US; Screening; Prostate-specific antigen; Prostate cancer; Healthcare claims
• ISSN: 0957-5243; 1573-7225
• DOI: 10.1007/s10552-020-01324-x

Purpose
This study describes longitudinal trends in the use of prostate-specific antigen (PSA)-based testing in two geographically distinct healthcare systems following the 2011 US Preventive Services Task Force (USPSTF) recommendations against routine PSA screening.
Methods
We analyzed population-based health claims data from 253,139 men aged 40–80 who were enrolled at two US healthcare systems. We assessed trends in the percentage of eligible men receiving ≥ 1 PSA test per year by time period (2000–2008, 2009–2011, 2012–2014), age (40–54, 55–69, 70–80), and race (white, black, other, unknown), and conducted a joinpoint regression analysis.
Results
Men aged 55–69 and 70–80 years of all races had similar use of PSA testing between 2000 and 2011, ranging between 47 and 56% of eligible men by year, while only 22–26% of men aged 40–54 had a PSA test per year during this period. Overall, the percentage of men receiving at least one PSA test per year decreased by 26% between 2009–2011 and 2012–2014, with similar trends across race and age groups. PSA testing declined significantly after 2011 (annual percent change = − 11.28).
Conclusions
Following the 2011 USPSTF recommendations against routine PSA screening, declines in PSA testing were observed among men of all races and across all age groups in two large US healthcare systems.