Albizzia chinensis (Osbeck) Merr extract YS ameliorates ethanol‐induced acute gastric ulcer injury in rats by regulating NRF2 signaling pathway
Background Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on...
Saved in:
| Published in: | Animal models and experimental medicine Vol. 7; no. 3; pp. 275 - 282 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
John Wiley & Sons, Inc
01-06-2024
John Wiley and Sons Inc Wiley |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Background
Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ethanol.
Methods
The ethanol‐induced gastric ulcer rat model was used to assess the protective effect of YS. A pathological examination of gastric tissue was performed by H&E staining. GES‐1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial cells. Endogenous NRF2 was knocked down using small interfering RNA. Immunoprecipitation was used to detect ubiquitination of NRF2. Co‐immunoprecipitation was used to detect the NRF2–Keap1 interaction.
Results
YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index, decreased MDA level, and increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO‐1 expression levels in injured rat gastric tissue. In addition, YS regulated NQO1 and HO‐1 via NRF2 in H2O2‐induced oxidative injured GES‐1 cells. Further studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2, thereby increasing its stability and expression of downstream factors. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES‐1 cells treated with H2O2.
Conclusion
YS reduced the NRF2–Keap1 interaction, promoting NRF2 translocation into the nucleus, which increasing the transcription and translation of NQO1 and HO‐1 and improved the antioxidant capacity of rat stomach.
YS, extraction from Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases, which has been patented. Here we elucidated the protective effect and underling action mechanism of YS on gastric ulcer in rats injured by ethanol. YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index and histopathological injury, decreased MDA level, increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO‐1 expression level in injured rat gastric tissue. In addition, YS regulated NQO1 and HO‐1 via NRF2 in H2O2‐induced oxidative injured GES‐1 cells. Further studies on the underlying mechanism indicated that YS reduced the NRF2 and Keap1 interaction, decreased ubiquitylation of NRF2, thereby increasing its stability and downstream factors expression. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES‐1 cells treated by H2O2. Its gastric protective effect is attributed to YS reducing NRF2‐Keap1 interaction, promoting NRF2 translocation into the nucleus, increasing the transcription and translation of NQO1 and HO‐1, improving the antioxidant capacity of rat stomach. |
|---|---|
| AbstractList | Background
Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ethanol.
Methods
The ethanol‐induced gastric ulcer rat model was used to assess the protective effect of YS. A pathological examination of gastric tissue was performed by H&E staining. GES‐1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial cells. Endogenous NRF2 was knocked down using small interfering RNA. Immunoprecipitation was used to detect ubiquitination of NRF2. Co‐immunoprecipitation was used to detect the NRF2–Keap1 interaction.
Results
YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index, decreased MDA level, and increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO‐1 expression levels in injured rat gastric tissue. In addition, YS regulated NQO1 and HO‐1 via NRF2 in H2O2‐induced oxidative injured GES‐1 cells. Further studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2, thereby increasing its stability and expression of downstream factors. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES‐1 cells treated with H2O2.
Conclusion
YS reduced the NRF2–Keap1 interaction, promoting NRF2 translocation into the nucleus, which increasing the transcription and translation of NQO1 and HO‐1 and improved the antioxidant capacity of rat stomach.
YS, extraction from Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases, which has been patented. Here we elucidated the protective effect and underling action mechanism of YS on gastric ulcer in rats injured by ethanol. YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index and histopathological injury, decreased MDA level, increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO‐1 expression level in injured rat gastric tissue. In addition, YS regulated NQO1 and HO‐1 via NRF2 in H2O2‐induced oxidative injured GES‐1 cells. Further studies on the underlying mechanism indicated that YS reduced the NRF2 and Keap1 interaction, decreased ubiquitylation of NRF2, thereby increasing its stability and downstream factors expression. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES‐1 cells treated by H2O2. Its gastric protective effect is attributed to YS reducing NRF2‐Keap1 interaction, promoting NRF2 translocation into the nucleus, increasing the transcription and translation of NQO1 and HO‐1, improving the antioxidant capacity of rat stomach. Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ethanol. The ethanol-induced gastric ulcer rat model was used to assess the protective effect of YS. A pathological examination of gastric tissue was performed by H&E staining. GES-1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial cells. Endogenous NRF2 was knocked down using small interfering RNA. Immunoprecipitation was used to detect ubiquitination of NRF2. Co-immunoprecipitation was used to detect the NRF2-Keap1 interaction. YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index, decreased MDA level, and increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO-1 expression levels in injured rat gastric tissue. In addition, YS regulated NQO1 and HO-1 via NRF2 in H O -induced oxidative injured GES-1 cells. Further studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2, thereby increasing its stability and expression of downstream factors. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES-1 cells treated with H O . YS reduced the NRF2-Keap1 interaction, promoting NRF2 translocation into the nucleus, which increasing the transcription and translation of NQO1 and HO-1 and improved the antioxidant capacity of rat stomach. BackgroundAround the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ethanol.MethodsThe ethanol-induced gastric ulcer rat model was used to assess the protective effect of YS. A pathological examination of gastric tissue was performed by H&E staining. GES-1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial cells. Endogenous NRF2 was knocked down using small interfering RNA. Immunoprecipitation was used to detect ubiquitination of NRF2. Co-immunoprecipitation was used to detect the NRF2–Keap1 interaction.ResultsYS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index, decreased MDA level, and increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO-1 expression levels in injured rat gastric tissue. In addition, YS regulated NQO1 and HO-1 via NRF2 in H2O2-induced oxidative injured GES-1 cells. Further studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2, thereby increasing its stability and expression of downstream factors. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES-1 cells treated with H2O2.ConclusionYS reduced the NRF2–Keap1 interaction, promoting NRF2 translocation into the nucleus, which increasing the transcription and translation of NQO1 and HO-1 and improved the antioxidant capacity of rat stomach. Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ethanol.BACKGROUNDAround the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ethanol.The ethanol-induced gastric ulcer rat model was used to assess the protective effect of YS. A pathological examination of gastric tissue was performed by H&E staining. GES-1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial cells. Endogenous NRF2 was knocked down using small interfering RNA. Immunoprecipitation was used to detect ubiquitination of NRF2. Co-immunoprecipitation was used to detect the NRF2-Keap1 interaction.METHODSThe ethanol-induced gastric ulcer rat model was used to assess the protective effect of YS. A pathological examination of gastric tissue was performed by H&E staining. GES-1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial cells. Endogenous NRF2 was knocked down using small interfering RNA. Immunoprecipitation was used to detect ubiquitination of NRF2. Co-immunoprecipitation was used to detect the NRF2-Keap1 interaction.YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index, decreased MDA level, and increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO-1 expression levels in injured rat gastric tissue. In addition, YS regulated NQO1 and HO-1 via NRF2 in H2O2-induced oxidative injured GES-1 cells. Further studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2, thereby increasing its stability and expression of downstream factors. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES-1 cells treated with H2O2.RESULTSYS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index, decreased MDA level, and increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO-1 expression levels in injured rat gastric tissue. In addition, YS regulated NQO1 and HO-1 via NRF2 in H2O2-induced oxidative injured GES-1 cells. Further studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2, thereby increasing its stability and expression of downstream factors. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES-1 cells treated with H2O2.YS reduced the NRF2-Keap1 interaction, promoting NRF2 translocation into the nucleus, which increasing the transcription and translation of NQO1 and HO-1 and improved the antioxidant capacity of rat stomach.CONCLUSIONYS reduced the NRF2-Keap1 interaction, promoting NRF2 translocation into the nucleus, which increasing the transcription and translation of NQO1 and HO-1 and improved the antioxidant capacity of rat stomach. Abstract Background Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases. Here we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ethanol. Methods The ethanol‐induced gastric ulcer rat model was used to assess the protective effect of YS. A pathological examination of gastric tissue was performed by H&E staining. GES‐1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial cells. Endogenous NRF2 was knocked down using small interfering RNA. Immunoprecipitation was used to detect ubiquitination of NRF2. Co‐immunoprecipitation was used to detect the NRF2–Keap1 interaction. Results YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index, decreased MDA level, and increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO‐1 expression levels in injured rat gastric tissue. In addition, YS regulated NQO1 and HO‐1 via NRF2 in H2O2‐induced oxidative injured GES‐1 cells. Further studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2, thereby increasing its stability and expression of downstream factors. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES‐1 cells treated with H2O2. Conclusion YS reduced the NRF2–Keap1 interaction, promoting NRF2 translocation into the nucleus, which increasing the transcription and translation of NQO1 and HO‐1 and improved the antioxidant capacity of rat stomach. YS, extraction from Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases, which has been patented. Here we elucidated the protective effect and underling action mechanism of YS on gastric ulcer in rats injured by ethanol. YS (10 and 30 mg/kg, i.g.) significantly reduced the ulcer index and histopathological injury, decreased MDA level, increased SOD and GSH levels in gastric tissues damaged by ethanol. YS promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO‐1 expression level in injured rat gastric tissue. In addition, YS regulated NQO1 and HO‐1 via NRF2 in H 2 O 2 ‐induced oxidative injured GES‐1 cells. Further studies on the underlying mechanism indicated that YS reduced the NRF2 and Keap1 interaction, decreased ubiquitylation of NRF2, thereby increasing its stability and downstream factors expression. NRF2 knockdown abolished the effect of YS on MDA and SOD in GES‐1 cells treated by H 2 O 2 . Its gastric protective effect is attributed to YS reducing NRF2‐Keap1 interaction, promoting NRF2 translocation into the nucleus, increasing the transcription and translation of NQO1 and HO‐1, improving the antioxidant capacity of rat stomach. |
| Author | Wang, Guibin Yu, Shishan Tang, Bo Yu, Yuanzhi Zhang, Jianjun Ma, Shuanggang Li, Liangning |
| AuthorAffiliation | 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing China 1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China 2 State Key Laboratory of Digestive Health Beijing China |
| AuthorAffiliation_xml | – name: 2 State Key Laboratory of Digestive Health Beijing China – name: 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing China – name: 1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China |
| Author_xml | – sequence: 1 givenname: Bo orcidid: 0000-0003-4112-7203 surname: Tang fullname: Tang, Bo organization: State Key Laboratory of Digestive Health – sequence: 2 givenname: Liangning surname: Li fullname: Li, Liangning organization: State Key Laboratory of Digestive Health – sequence: 3 givenname: Yuanzhi surname: Yu fullname: Yu, Yuanzhi organization: State Key Laboratory of Digestive Health – sequence: 4 givenname: Guibin surname: Wang fullname: Wang, Guibin organization: State Key Laboratory of Digestive Health – sequence: 5 givenname: Shuanggang surname: Ma fullname: Ma, Shuanggang organization: State Key Laboratory of Bioactive Substance and Function of Natural Medicines – sequence: 6 givenname: Shishan surname: Yu fullname: Yu, Shishan organization: State Key Laboratory of Bioactive Substance and Function of Natural Medicines – sequence: 7 givenname: Jianjun surname: Zhang fullname: Zhang, Jianjun email: jjzhang@imm.ac.cn organization: State Key Laboratory of Digestive Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38659237$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstu1DAUhiNURC90wwMgS2wK0hTf4iQrNKpaqNRSicuCleXLScaDxxnshHa64hHgFXkSPJ1StSxY-fb5O0dH_26xFfoARfGM4EOCMX2tFkAPCeWYPCp2aFmJCcVNuXVvv13spzTHGcaEcSyeFNusFmVDWbVT_Jp67a6vnUJm5gKE5BI6uEgazNeX6BxiRHA1RGUG9OUjyrW866MaICEYZir0_vePny7Y0YBFyowDoE6lITqDRm8gIhfmY1zlBeVfCekVitCNXg0udOj9hxOKkuuC8uvjUg2zS7V6WjxulU-wf7vuFZ9Pjj8dvZucXbw9PZqeTQyvOJlQyk3VqpbXTdNqppu2JK21GFeYGkqtZXUDFmtFOAXRioozbmutOdMEC1ayveJ047W9mstldAsVV7JXTt5c9LGTKg7OeJCVzbUUA0GM4NS0SlhoCTXa4jarSHa92biWo16ANRDyzPwD6cOX4Gay679LQiitcc2z4eDWEPtvI6RBLlwy4L0K0I9JMsxFScqqaTL64h903o8xD3FNVYJXTV1XmXq1oUzsU4rQ3nVDsFwnR66TI2-Sk-Hn9_u_Q__mJANkA1w6D6v_qOT0_JhupH8Aqz3SFg |
| Cites_doi | 10.3389/fphar.2020.600295 10.1016/j.ab.2016.10.021 10.1155/2022/2169551 10.1016/j.biomaterials.2011.12.037 10.1016/j.biopha.2018.10.118 10.1016/j.fct.2017.07.023 10.1186/s12870-021-02919-5 10.1021/acs.jnatprod.2c00620 10.1016/j.biopha.2022.113200 10.1016/j.cvsm.2020.09.001 10.2147/IJN.S289515 10.1016/j.fct.2008.10.026 10.1016/j.apsb.2014.05.001 10.4291/wjgp.v5.i1.40 10.1007/s00204-011-0674-5 10.1155/2018/3585394 10.1016/j.freeradbiomed.2022.02.007 10.1007/BF01536637 10.1111/j.1365-2362.2010.02419.x 10.1016/j.biopha.2020.110075 10.1016/j.btre.2018.e00256 10.3748/wjg.v20.i45.17020 10.3389/fnut.2021.697879 10.1016/j.redox.2012.10.001 10.1515/jcim-2021-0264 10.1111/j.1600-079X.2007.00443.x 10.1002/med.21396 10.1111/j.1530-0277.2006.00319.x 10.1111/j.1440-1746.1998.tb01877.x 10.1016/j.bbagen.2015.01.008 10.1016/j.freeradbiomed.2015.05.034 10.3390/ijms20205128 10.1136/bmj.l536 10.1111/bcpt.13023 10.1089/ars.2010.3222 10.1016/j.freeradbiomed.2015.06.021 10.1002/med.21257 |
| ContentType | Journal Article |
| Copyright | 2024 The Author(s). published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. 2024 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2024 The Author(s). published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. – notice: 2024 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. – notice: 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 8FE 8FH ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M7P PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1002/ame2.12401 |
| DatabaseName | Wiley-Blackwell Open Access Collection Wiley Free Archive Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) Biological Sciences Biological Science Database Publicly Available Content Database (Proquest) (PQ_SDU_P3) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Biological Science Collection ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest One Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Tang et al |
| EISSN | 2576-2095 |
| EndPage | 282 |
| ExternalDocumentID | oai_doaj_org_article_7d4c7a3e61c642cfa6def12cbd0f6351 10_1002_ame2_12401 38659237 AME212401 |
| Genre | article Journal Article |
| GeographicLocations | Beijing China China |
| GeographicLocations_xml | – name: China – name: Beijing China |
| GrantInformation_xml | – fundername: Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University funderid: 202105AG070012 – fundername: Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University grantid: 202105AG070012 |
| GroupedDBID | -SE -S~ 0R~ 1OC 24P 8FE 8FH AAHBH AAHHS AAXDM ACCFJ ACXQS ADBBV ADKYN ADPDF ADZMN ADZOD AEEZP AEQDE AFKRA AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS AOIJS AVUZU BBNVY BCNDV BENPR BHPHI CAJEE CCPQU EBS EJD EMOBN GROUPED_DOAJ HCIFZ HYE IAO IHR INH LK8 M7P OK1 OVD OVEED PIMPY PROAC Q-- RPM TCJ TEORI TGQ U1G U5O WFFXF WIN CGR CUY CVF ECM EIF ITC NPM AAYXX CITATION ABUWG AZQEC DWQXO GNUQQ PQEST PQQKQ PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c4741-224c7faf4899fb3b9f51fdd00702c22dd389ed0ba142e6f67434d8bb43b106353 |
| IEDL.DBID | RPM |
| ISSN | 2576-2095 2096-5451 |
| IngestDate | Tue Oct 22 15:14:51 EDT 2024 Tue Sep 17 21:28:42 EDT 2024 Sat Oct 26 04:43:09 EDT 2024 Thu Oct 10 22:58:31 EDT 2024 Fri Nov 22 03:03:21 EST 2024 Sat Nov 02 11:54:33 EDT 2024 Sat Aug 24 00:42:19 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | YS antioxidative NRF2 gastric ulcer ethanol |
| Language | English |
| License | Attribution-NonCommercial 2024 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4741-224c7faf4899fb3b9f51fdd00702c22dd389ed0ba142e6f67434d8bb43b106353 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4112-7203 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228084/ |
| PMID | 38659237 |
| PQID | 3076479887 |
| PQPubID | 4365297 |
| PageCount | 8 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7d4c7a3e61c642cfa6def12cbd0f6351 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11228084 proquest_miscellaneous_3046515799 proquest_journals_3076479887 crossref_primary_10_1002_ame2_12401 pubmed_primary_38659237 wiley_primary_10_1002_ame2_12401_AME212401 |
| PublicationCentury | 2000 |
| PublicationDate | June 2024 |
| PublicationDateYYYYMMDD | 2024-06-01 |
| PublicationDate_xml | – month: 06 year: 2024 text: June 2024 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Animal models and experimental medicine |
| PublicationTitleAlternate | Animal Model Exp Med |
| PublicationYear | 2024 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2021; 8 2009; 47 2021; 21 2022; 151 2013; 1 2010; 13 2018; 123 2020; 126 2015; 1850 1988; 33 2022; 85 2019; 109 2022; 20 2020; 11 2007; 31 2021; 51 2012; 33 2019; 364 2016; 36 2012; 32 2014; 20 2017; 108 2021; 16 2018; 18 2014; 5 2018; 2018 2014; 4 2022; 2022 2019; 20 2022; 181 2015; 88 2011; 41 2011; 85 2007; 43 2017; 524 1998; 13 e_1_2_10_23_1 e_1_2_10_24_1 e_1_2_10_21_1 e_1_2_10_22_1 e_1_2_10_20_1 e_1_2_10_2_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_3_1 e_1_2_10_19_1 e_1_2_10_6_1 e_1_2_10_16_1 e_1_2_10_5_1 e_1_2_10_17_1 e_1_2_10_38_1 e_1_2_10_8_1 e_1_2_10_14_1 e_1_2_10_37_1 e_1_2_10_7_1 e_1_2_10_15_1 e_1_2_10_36_1 e_1_2_10_12_1 e_1_2_10_35_1 e_1_2_10_9_1 e_1_2_10_13_1 e_1_2_10_34_1 e_1_2_10_10_1 e_1_2_10_33_1 e_1_2_10_11_1 e_1_2_10_32_1 e_1_2_10_31_1 e_1_2_10_30_1 e_1_2_10_29_1 e_1_2_10_27_1 e_1_2_10_28_1 e_1_2_10_25_1 e_1_2_10_26_1 |
| References_xml | – volume: 85 start-page: 2406 issue: 10 year: 2022 end-page: 2412 article-title: Effects of the anthocyanin Hirsutidin on gastric ulcers: improved healing through antioxidant mechanisms publication-title: J Nat Prod – volume: 151 year: 2022 article-title: AMPK/mTOR‐driven autophagy & Nrf2/HO‐1 cascade modulation by amentoflavone ameliorates indomethacin‐induced gastric ulcer publication-title: Biomed Pharmacother – volume: 8 year: 2021 article-title: Lycopene aggravates acute gastric injury induced by ethanol publication-title: Front Nutr – volume: 2018 year: 2018 article-title: Antioxidative and anti‐inflammatory effects of water extract of Acrostichum aureum Linn. Against ethanol‐induced gastric ulcer in rats publication-title: Evid Based Complement Alternat Med – volume: 524 start-page: 13 year: 2017 end-page: 30 article-title: Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges publication-title: Anal Biochem – volume: 41 start-page: 380 issue: 4 year: 2011 end-page: 386 article-title: Effects of long‐term PPI treatment on producing bowel symptoms and SIBO publication-title: Eur J Clin Investig – volume: 364 year: 2019 article-title: Management of acute upper gastrointestinal bleeding publication-title: BMJ – volume: 31 start-page: 390 issue: 3 year: 2007 end-page: 394 article-title: Protective effects of the whisky congeners on ethanol‐induced gastric mucosal damage publication-title: Alcohol Clin Exp Res – volume: 13 start-page: 1665 issue: 11 year: 2010 end-page: 1678 article-title: Discovery of the negative regulator of Nrf2, Keap1: a historical overview publication-title: Antioxid Redox Signal – volume: 13 start-page: S199 issue: S3 year: 1998 end-page: S203 article-title: Cigarette smoking: effects on P selectin expression and subsequent inflammatory responses in ethanol‐induced gastric mucosal damage publication-title: J Gastroenterol Hepatol – volume: 20 start-page: 17020 issue: 45 year: 2014 end-page: 17028 article-title: Efficacy and safety of herbal medicines in treating gastric ulcer: a review publication-title: World J Gastroenterol – volume: 18 year: 2018 article-title: Biotechnological aspects of plants metabolites in the treatment of ulcer: a new prospective publication-title: Biotechnol Rep (Amst) – volume: 181 start-page: 221 year: 2022 end-page: 234 article-title: Omeprazole prevents stress induced gastric ulcer by direct inhibition of MMP‐2/TIMP‐3 interactions publication-title: Free Radic Biol Med – volume: 88 start-page: 108 year: 2015 end-page: 146 article-title: Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease publication-title: Free Radic Biol Med – volume: 2022 year: 2022 article-title: Correlation between endoscopic morphology and bleeding of gastric ulcer publication-title: J Healthc Eng – volume: 33 start-page: 92 issue: 1 year: 1988 end-page: 105 article-title: A biochemical and pharmacological approach to the genesis of ulcer disease. I. A model study of ethanol‐induced injury to gastric mucosa in rats publication-title: Dig Dis Sci – volume: 1 start-page: 45 issue: 1 year: 2013 end-page: 49 article-title: The Keap1‐Nrf2 pathway: mechanisms of activation and dysregulation in cancer publication-title: Redox Biol – volume: 85 start-page: 241 issue: 4 year: 2011 end-page: 272 article-title: The cytoprotective role of the Keap1‐Nrf2 pathway publication-title: Arch Toxicol – volume: 126 year: 2020 article-title: Gastroprotective effect of gallic acid against ethanol‐induced gastric ulcer in rats: involvement of the Nrf2/HO‐1 signaling and anti‐apoptosis role publication-title: Biomed Pharmacother – volume: 32 start-page: 687 issue: 4 year: 2012 end-page: 726 article-title: Small molecule modulators of Keap1‐Nrf2‐ARE pathway as potential preventive and therapeutic agents publication-title: Med Res Rev – volume: 20 start-page: 665 issue: 4 year: 2022 end-page: 674 article-title: Plants with potential anti‐ulcerogenic activity and possible mechanism of actions based on their phyto‐constitutional profile publication-title: J Complement Integr Med – volume: 123 start-page: 114 issue: 2 year: 2018 end-page: 121 article-title: Side effects of long‐term proton pump inhibitor use: a review publication-title: Basic Clin Pharmacol Toxicol – volume: 4 start-page: 358 issue: 5 year: 2014 end-page: 367 article-title: Antiulcerogenic activity of on gastric ulcers induced by ethanol in rats publication-title: Acta Pharm Sin B – volume: 88 start-page: 101 year: 2015 end-page: 107 article-title: Structural basis of Keap1 interactions with Nrf2 publication-title: Free Radic Biol Med – volume: 108 start-page: 104 year: 2017 end-page: 119 article-title: Antiulcer properties of fruits and vegetables: a mechanism based perspective publication-title: Food Chem Toxicol – volume: 33 start-page: 2991 issue: 10 year: 2012 end-page: 3001 article-title: The use of nano‐quercetin to arrest mitochondrial damage and MMP‐9 upregulation during prevention of gastric inflammation induced by ethanol in rat publication-title: Biomaterials – volume: 1850 start-page: 769 issue: 4 year: 2015 end-page: 783 article-title: Morin protects gastric mucosa from nonsteroidal anti‐inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF‐κB pathway publication-title: Biochim Biophys Acta – volume: 43 start-page: 56 issue: 1 year: 2007 end-page: 64 article-title: Matrix metalloproteinase‐9 activity and expression is reduced by melatonin during prevention of ethanol‐induced gastric ulcer in mice publication-title: J Pineal Res – volume: 47 start-page: 134 issue: 1 year: 2009 end-page: 139 article-title: Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats publication-title: Food Chem Toxicol – volume: 11 year: 2020 article-title: Rutaecarpine ameliorates ethanol‐induced gastric mucosal injury in mice by modulating genes related to inflammation, oxidative stress and apoptosis publication-title: Front Pharmacol – volume: 109 start-page: 314 year: 2019 end-page: 321 article-title: aspirin‐induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation publication-title: Biomed Pharmacother – volume: 21 issue: 1 year: 2021 article-title: Superoxide dismutase (SOD) as a selection criterion for triticale grain yield under drought stress: a comprehensive study on genomics and expression profiling, bioinformatics, heritability, and phenotypic variability publication-title: BMC Plant Biol – volume: 5 start-page: 40 issue: 1 year: 2014 end-page: 47 article-title: Quality of healing of gastric ulcers: natural products beyond acid suppression publication-title: World J Gastrointest Pathophysiol – volume: 16 start-page: 2461 year: 2021 end-page: 2475 article-title: Protective effects of radix Sophorae Flavescentis Carbonisata‐based carbon dots against ethanol‐induced acute gastric ulcer in rats: anti‐inflammatory and antioxidant activities publication-title: Int J Nanomedicine – volume: 36 start-page: 924 issue: 5 year: 2016 end-page: 963 article-title: The Keap1‐Nrf2‐ARE pathway As a potential preventive and therapeutic target: an update publication-title: Med Res Rev – volume: 51 start-page: 33 issue: 1 year: 2021 end-page: 41 article-title: Gastroprotective therapy publication-title: Vet Clin North Am Small Anim Pract – volume: 20 start-page: 5128 issue: 20 year: 2019 end-page: 5173 article-title: Insights into effects/risks of chronic Hypergastrinemia and lifelong PPI treatment in Man based on studies of patients with Zollinger‐Ellison syndrome publication-title: Int J Mol Sci – ident: e_1_2_10_11_1 doi: 10.3389/fphar.2020.600295 – ident: e_1_2_10_34_1 doi: 10.1016/j.ab.2016.10.021 – ident: e_1_2_10_2_1 doi: 10.1155/2022/2169551 – ident: e_1_2_10_10_1 doi: 10.1016/j.biomaterials.2011.12.037 – ident: e_1_2_10_13_1 doi: 10.1016/j.biopha.2018.10.118 – ident: e_1_2_10_27_1 doi: 10.1016/j.fct.2017.07.023 – ident: e_1_2_10_33_1 doi: 10.1186/s12870-021-02919-5 – ident: e_1_2_10_14_1 doi: 10.1021/acs.jnatprod.2c00620 – ident: e_1_2_10_37_1 doi: 10.1016/j.biopha.2022.113200 – ident: e_1_2_10_4_1 doi: 10.1016/j.cvsm.2020.09.001 – ident: e_1_2_10_12_1 doi: 10.2147/IJN.S289515 – ident: e_1_2_10_9_1 doi: 10.1016/j.fct.2008.10.026 – ident: e_1_2_10_6_1 doi: 10.1016/j.apsb.2014.05.001 – ident: e_1_2_10_25_1 doi: 10.4291/wjgp.v5.i1.40 – ident: e_1_2_10_36_1 doi: 10.1007/s00204-011-0674-5 – ident: e_1_2_10_31_1 doi: 10.1155/2018/3585394 – ident: e_1_2_10_8_1 doi: 10.1016/j.freeradbiomed.2022.02.007 – ident: e_1_2_10_28_1 doi: 10.1007/BF01536637 – ident: e_1_2_10_23_1 doi: 10.1111/j.1365-2362.2010.02419.x – ident: e_1_2_10_15_1 doi: 10.1016/j.biopha.2020.110075 – ident: e_1_2_10_24_1 doi: 10.1016/j.btre.2018.e00256 – ident: e_1_2_10_18_1 doi: 10.3748/wjg.v20.i45.17020 – ident: e_1_2_10_29_1 doi: 10.3389/fnut.2021.697879 – ident: e_1_2_10_17_1 doi: 10.1016/j.redox.2012.10.001 – ident: e_1_2_10_26_1 doi: 10.1515/jcim-2021-0264 – ident: e_1_2_10_19_1 doi: 10.1111/j.1600-079X.2007.00443.x – ident: e_1_2_10_21_1 doi: 10.1002/med.21396 – ident: e_1_2_10_30_1 doi: 10.1111/j.1530-0277.2006.00319.x – ident: e_1_2_10_32_1 doi: 10.1111/j.1440-1746.1998.tb01877.x – ident: e_1_2_10_7_1 doi: 10.1016/j.bbagen.2015.01.008 – ident: e_1_2_10_16_1 doi: 10.1016/j.freeradbiomed.2015.05.034 – ident: e_1_2_10_22_1 doi: 10.3390/ijms20205128 – ident: e_1_2_10_3_1 doi: 10.1136/bmj.l536 – ident: e_1_2_10_5_1 doi: 10.1111/bcpt.13023 – ident: e_1_2_10_20_1 doi: 10.1089/ars.2010.3222 – ident: e_1_2_10_35_1 doi: 10.1016/j.freeradbiomed.2015.06.021 – ident: e_1_2_10_38_1 doi: 10.1002/med.21257 |
| SSID | ssj0002013406 ssib051367487 ssib039590021 ssib051604368 |
| Score | 2.309331 |
| Snippet | Background
Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential... Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic... BackgroundAround the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has potential... YS, extraction from Chinese herb Albizzia chinensis (Osbeck) Merr, has potential therapeutic applications for gastrointestinal diseases, which has been... Abstract Background Around the world, there is a high incidence of gastric ulcers. YS, an extract from the Chinese herb Albizzia chinensis (Osbeck) Merr, has... |
| SourceID | doaj pubmedcentral proquest crossref pubmed wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 275 |
| SubjectTerms | Alcohol use Animals Antibodies Antioxidants antioxidative Cytoplasm Drug dosages Epithelial cells Ethanol Gastric mucosa Gastric Mucosa - drug effects Gastric Mucosa - injuries Gastric Mucosa - metabolism gastric ulcer Gastrointestinal diseases Herbal medicine Hydrogen peroxide Immunoprecipitation Kelch-Like ECH-Associated Protein 1 - metabolism Laboratory animals Male Neutrophils NF-E2-Related Factor 2 - metabolism NRF2 NRF2 protein Original Oxidative stress Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Sprague-Dawley Signal transduction Signal Transduction - drug effects siRNA Statistical analysis Stomach Ulcer - chemically induced Stomach Ulcer - metabolism Themed Section: Traditional Chinese Medicines and Natural Medicines Research Therapeutic applications Ubiquitin Ubiquitination Ulcers |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagJy4IVB6hDxnBAZBCHcebx3GBXXFpkShIcLL8hC3bLEoaVe2JnwB_kV_CjJ2NugLBhVOiJJacmbHnm2TmG0IeK8NqY1iZKm6KVFRWpMplNs2Z4-CeWQGLHT9dHJdHH6pXM6TJGVt9YU5YpAeOgjsorTClyl2RGYDKxqvCOp9xoy3z4Cxj4MOKK8HUSfi9luXgqkY-Un6gTh1_Ds5s6P6y9kCBqP9P6PL3JMmr4DV4n_ktcnOAjXQap3ubXHPNNvkxXerF5eVCUUyIxEz0jj5504G8vjylh65tKey8WAVFPx5TmNkSy_EBWlKH38tXy5_fvkNEDrq1VJn-zNFPCrt4GNovjWvpojkBgcOBwqiO6gvaxsb14O3o0ds5p5j8obCenWJj43N1cYe8n8_evXydDi0WUiMAS6TgwE3plRcQdnmd69pPMm8tkgBxw7m1gGecZVplgrvCY8WCsJXWItcg9HyS3yVbzapx97H424KKLABABSGmnlTMiqx0HoSvapXxhDxai11-jUwaMnImc4nKkUE5CXmBGhmfQPbrcAFsQg42If9lEwnZXetTDkuyk7CZFQLZ2cqEPBxvw2LCPySqcasenwmt4cu6Tsi9qP5xJtgcFdAwjK42DGNjqpt3msXnQNgNmJZXrBIJeRZs6C_vL6eHMx7OHvwPSeyQGxxQWMxt2yVbZ23v9sj1zvb7YcH8AgKaHlQ priority: 102 providerName: Directory of Open Access Journals |
| Title | Albizzia chinensis (Osbeck) Merr extract YS ameliorates ethanol‐induced acute gastric ulcer injury in rats by regulating NRF2 signaling pathway |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fame2.12401 https://www.ncbi.nlm.nih.gov/pubmed/38659237 https://www.proquest.com/docview/3076479887 https://www.proquest.com/docview/3046515799 https://pubmed.ncbi.nlm.nih.gov/PMC11228084 https://doaj.org/article/7d4c7a3e61c642cfa6def12cbd0f6351 |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6RnrggEC9DWy2CAyA5sdfr1zGURFxSEAUJTta-nBocp7JrVe2JnwB_kV_CzDp2sUAcOCWKX2PPjOebzcw3hDwTykuV8mJXMBW5PNHcFcbXbuAZBuHZi8DZceniJD7-lLxeIE1O1PfC2KJ9JYtpVW6mVXFqayvPNmrW14nN3q2OACOwxEv4bEImAA7HOXqQ4iDM66AUIikZvwYhoR9Z2vVhJQZCYMDtEE4GeN4FSOEPPKZsJjaGTSEIejhTBgdkAiKKR0HMcv3_DaD-WWf5O_61AWx5m9zaIU867-7wDrlhqrvkx7yUxdVVISjWVGIxe0Ofv23gkX99QVemrim8vLGRin4-oSBkiR39gE6pwSX3bfnz23dI6sE8NBWqPTd0LXAQiKJtqUxNi-oL6Aw-KBzVUHlJa7O2A8OqNT1-v2QU60cEtsRTnI18IS7vkY_LxYejN-5uSoOrOMARFzCAinORc8jcchnINA_9XGvkEWKKMa0BEhntSeFzZqIcmx64TqTkgYR0NAiD-2Sv2lbmIfaPa19FGjCkgCxVhomnuR-bHPQgUuEzhzztH3t21pFxZB3tMstQT5nVk0NeoUaGPZBA2_6wrdfZzoyyWIPUIjARXJAzlYtIm9xnSmovB6HgJPu9PrOdVzcZvA8jjgRvsUOeDJvBH_FPFlGZbYv72OnycZo65EGn_kGS3nwckowMYyTqeAu4gOX87k3eIS-tDf3j_rP5asHst0f_f53H5CYD-NYVxe2TvfO6NQdk0uj20C5bHFqf-wUQkyue |
| link.rule.ids | 230,315,729,782,786,866,887,2106,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF7RcoALD_GoocAiOACSk_V6_TqGkqiIJiBaJDhZ-3IwJE5l10LtiZ8Af5FfwswmTolAHHpKlPVjVzO78-1m5vsIeSo1y7RmiS-5jn2RGuFLGxg_ZJZDeGYxTHY8ujhMJh_TV0OkyYm7WhiXtK9V2atm815Vfna5lcdz3e_yxPrvxnuAEXjKUtHfIpdhwjK2uUsPM5TCPA9LEdKSiXMYEgWxI15fn8VAEAyFk-HkgOh9ABXBmsmU9-Xc8h6EQYaqMiiRCZgo2Qhjju3_XxD170zLPxGwC2Gj6xcd_A1ybQVa6WDZfpNcstUt8nMwU-XZWSkppmNiHnxDn71twFpfn9OxrWsK6z7WYNFPhxRGN0MyAAC21OJp_WL26_uPsjLgWYZK3Z5YOpWoIaJpO9O2pmX1BcwNHxTuaqg6pbWdOq2xakon70ecYuqJxGp6irLK3-TpbfJhNDza2_dXAg--FoBkfIAPOilkIWDTV6hQZUUUFMYgBRHXnBsDaMoapmQguI0LrJcQJlVKhAp2smEU3iHb1aKyO1h6bgIdG4CfEja4KkqZEUFiCzCgzGTAPfKks1d-vOTxyJeMzTxHA-fOwB55iaZcX4Hc2-6HRT3NV0bIEwO9lqGN4YWC60LGxhYB18qwAjoFD9ntHCFfLQhNDktpLJAbLvHI43UzTGX8f0ZWdtHiNU6YPskyj9xd-s26J53feSTd8KiNrm62gAM5uvDOYTzywjnff8afD8ZD7r7du_h7HpEr-0fjg_zg9eTNfXKVAwpc5tbtku2TurUPyFZj2oduyv4GcjFAXA |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF7RIiEuPMTLpcAiOACSE3u98YNbaBOBIKGiINGTtc9gmjiRXQu1J34C_EV-CTObOCUCcYBTonhtrzOzO9-uZ76PkMdCBZlSQeILpmKfp5r7woTajwLDIDwHMQx23Lo4TMYf0_0B0uQ8b2thXNK-kkWnnM46ZfHJ5VYuZqrb5ol1D0Z7gBFYGqS8u9C2u0UuwqAN2OZKPcpQDvM8NPWQmoyfQ5FeGDvy9fV-DATCiDspTgao3gdgEa7ZTFlXzAzrQCgMUFkGZTIBFyUbocwx_v8Jpv6ebfkrCnZhbHj1f_6Aa-TKCrzS_rLNdXLBlDfI9_5UFmdnhaCYlon58DV98rYGqx0_pSNTVRTmf6zFokeHFJ5wiqQAAHCpwV37-fTH129FqcHDNBWqOTF0IlBLRNFmqkxFi_IzmB0-KJxVU3lKKzNxmmPlhI7fDRnFFBSBVfUU5ZW_iNOb5MNw8H7vpb8SevAVB0TjA4xQiRWWw-LPykhmthdarZGKiCnGtAZUZXQgRciZiS3WTXCdSskjCSvaqBfdItvlvDR3sARdhyrWAEMFLHRlLw00DxNjwYgiEyHzyKPWZvliyeeRL5mbWY5Gzp2RPfICzblugRzc7od5NclXhsgTDb0WkYnhhpwpK2JtbMiU1IGFTsFFdltnyFcTQ53DlBpz5IhLPPJwfRiGNL6nEaWZN9jGCdQnWeaR20vfWfek9T2PpBtetdHVzSPgRI42vHUajzxzDviX58_7owFz33b-_T4PyKWD_WH-5tX49V1ymQEYXKbY7ZLtk6ox98hWrZv7btT-BHydQtw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Albizzia+chinensis+%28Osbeck%29+Merr+extract+YS+ameliorates+ethanol%E2%80%90induced+acute+gastric+ulcer+injury+in+rats+by+regulating+NRF2+signaling+pathway&rft.jtitle=Animal+models+and+experimental+medicine&rft.au=Tang%2C+Bo&rft.au=Li%2C+Liangning&rft.au=Yu%2C+Yuanzhi&rft.au=Wang%2C+Guibin&rft.date=2024-06-01&rft.issn=2576-2095&rft.eissn=2576-2095&rft.volume=7&rft.issue=3&rft.spage=275&rft.epage=282&rft_id=info:doi/10.1002%2Fame2.12401&rft.externalDBID=10.1002%252Fame2.12401&rft.externalDocID=AME212401 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2576-2095&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2576-2095&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2576-2095&client=summon |