Controlled Delivery Achieved with Bi-Layer Matrix Devices Produced by Co-Injection Moulding

• Published in: Macromolecular bioscience Vol. 4; no. 8; pp. 795 - 801
• Main Authors: Vaz, Cláudia M., van Doeveren, Patrick F. N. M., Dias, Gustavo R., Reis, Rui L., Cunha, António M.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 09-08-2004; WILEY‐VCH Verlag
• Subjects: (co-)injection moulding; bi-layer devices; Biocompatible Materials - chemistry; Delayed-Action Preparations; Drug Delivery Systems; Hydrogen-Ion Concentration; Isoelectric Point; Materials Testing; Microscopy, Electron, Scanning; Solubility; Solutions - chemistry; soy protein; Soybean Proteins - chemistry; theophylline; Theophylline - administration & dosage; Theophylline - chemistry; Time Factors
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.200300060

The aim of this study was to design new soy protein‐based bi‐layered co‐injection moulded matrix systems aimed to achieve controlled drug delivery. The devices consisted of a drug‐free outer layer (skin) and a drug‐containing core. The systems overcame the inherent disadvantage of non‐linear release associated with diffusion‐controlled single‐layer matrix devices by providing additional releasing area with time to compensate for the decreasing release rate. As expected, the bi‐layer devices presented a significant decrease in drug release rate when compared with a correspondent single layer matrix system. The skin thickness and the degree of crosslinking of the core appeared to be very important tools to tailor the release patterns. Furthermore, due to the amphoteric nature of the soy protein, the developed devices evidenced a pH‐dependent behaviour. The mechanisms of drug release were also elucidated at two different pH values: i) pH 5.0, near the isoelectric point of soy (low matrix solubility); and ii) pH 7.4, physiological pH (high matrix solubility). Consequently, changing the release medium from pH 5.0 to pH 7.4 after two hours, led to an abrupt increase in drug release and the devices presented a typical controlled drug delivery profile: slow release/fast release. These evidences may provide for the development of individual systems with different release onsets that in combination may exhibit drug releases at predetermined times in a pre‐programmed way. Another possibility is the production of three‐layer devices presenting bimodal release profiles (fast release/slow release/fast release) by similar technologies.
Scanning electron micrograph of a developed bi‐layer device.