The effect of retro-inverse D-amino acid Aβ-peptides on Aβ-fibril formation

Peptides build from D-amino acids resist enzymatic degradation. The resulting extended time of biological activity makes them prime candidates for the development of pharmaceuticals. Of special interest are D-retro-inverso (DRI) peptides where a reversed sequence of D-amino acids leads to molecules...

Full description

Bibliographic Details

Published in:	The Journal of chemical physics Vol. 150; no. 9; p. 095101
Main Authors:	Xi, Wenhui, Hansmann, Ulrich H E
Format:	Journal Article
Language:	English
Published:	United States 07-03-2019
Subjects:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Amino Acids - chemistry Amino Acids - metabolism Amyloid - antagonists & inhibitors Amyloid - chemical synthesis Amyloid - chemistry Drug Design Humans Molecular Dynamics Simulation Solubility Stereoisomerism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!