Self-Sanitizing Polycaprolactone Electrospun Nanofiber Membrane with Ag Nanoparticles

• Published in: Journal of functional biomaterials Vol. 14; no. 7; p. 336
• Main Authors: Permyakova, Elizaveta S, Manakhov, Anton, Kiryukhantsev-Korneev, Philipp V, Konopatsky, Anton S, Makarets, Yulia A, Kotyakova, Kristina Yu, Filippovich, Svetlana Yu, Ignatov, Sergey G, Solovieva, Anastasiya O, Shtansky, Dmitry V
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25-06-2023; MDPI
• Subjects: Acids; Ag nanoparticles; Albinism; antibacterial activity; antifungal activity; Antimicrobial activity; Bacteria; Bacterial infections; Biodegradation; Biofilms; Cells; Computer software industry; Coronaviruses; COVID-19; Disease transmission; Electrostatic properties; Fabrication; face masks; Force and energy; Fungal infections; Gram-negative bacteria; Gram-positive bacteria; Health aspects; Health care; Ions; Masks; Medical dressings; Membranes; Microorganisms; Mortality; Nanofibers; Nanomaterials; Nanoparticles; Pandemics; Pathogens; Plasma; plasma polymerization; Polycaprolactone; polycaprolactone nanofibers; Polymers; Silver; Toxicity; Ultraviolet radiation; Water treatment; Israel; Russia; United States > US; antibacterial activity; plasma polymerization; polycaprolactone nanofibers; Ag nanoparticles; antifungal activity; face masks
• DOI: 10.3390/jfb14070336
• EISSN: 2079-4983

The objective of this research was to develop an environment-friendly and scalable method for the production of self-sanitizing electrospun nanofibers. This was achieved by immobilizing silver nanoparticles (Ag NPs) onto plasma-treated surfaces of biodegradable polycaprolactone (PCL) nanofibers. The plasma deposited polymer layer containing carboxyl groups played a critical role in providing a uniform distribution of Ag NPs on the nanofiber surface. Ag ions were absorbed by electrostatic interaction and then reduced under the action of UV-light. The concentration and release of Ag ions were analyzed using the EDXS/XPS and ICP AES methods, respectively. Although high levels of Ag ions were detected after 3 h of immersion in water, the material retained a sufficient amount of silver nanoparticles on the surface (~2.3 vs. 3.5 at.% as determined by XPS), and the release rate subsequently decreased over the next 69 h. The antipathogenic properties of PCL-Ag were tested against gram-negative and gram-positive bacteria, fungi, and biofilm formation. The results showed that the PCL-Ag nanofibers exhibit significant antimicrobial activity against a wide range of microorganisms, including those that cause human infections. The incorporation of Ag NPs into PCL nanofibers resulted in a self-sanitizing material that can be used in variety of applications, including wound dressings, water treatment, and air filtration. The development of a simple, scalable, and environmentally friendly method for the fabrication of these nanofibers is essential to ensure their widespread use in various industries. The ability to control the concentration and release rate of Ag ions in the PCL nanofibers will be critical to optimize their efficacy while minimizing their potential toxicity to human cells and the environment.