In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels

Synthetic mimics of antimicrobial peptides (AMPs) is a promising class of molecules for a variety of antimicrobial applications. Several hurdles must be passed before effective systemic infection therapies with AMPs can be achieved, but the path to effective topical treatment of skin, nail, and soft...

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 74; no. 5; pp. 337 - 345
Main Authors:	Håkansson, Joakim, Cavanagh, Jorunn Pauline, Stensen, Wenche, Mortensen, Bjarte, Svendsen, John-Sigurd, Svenson, Johan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-05-2021 Nature Publishing Group
Subjects:	14/19 631/154/309/2144 64/60 692/308/1426 Animals Anti-Bacterial Agents - pharmacology Antibiotic resistance antibiotics Bacteriology Bandages Biomedical and Life Sciences Bioorganic Chemistry Biotechnology & Applied Microbiology Bridged Bicyclo Compounds, Heterocyclic - pharmacology cationic antimicrobial peptides Diterpenes - pharmacology Drug Design efficacy Farmakologi och toxikologi Female Fusidic Acid - pharmacology Gels Immunology Infections Life Sciences Medicinal Chemistry methicillin-resistant Mice Mice, Inbred BALB C Microbiology mouse model Organic Chemistry Peptides peptidomimetics Pharmacology & Pharmacy Pharmacology and Toxicology Pilot Projects Pore Forming Cytotoxic Proteins - chemistry Pore Forming Cytotoxic Proteins - pharmacology Skin stability Staphylococcus aureus - drug effects staphylococcus-aureus Wound Healing
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