Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism

• Published in: iScience Vol. 26; no. 7; p. 107046
• Main Authors: Haran, Arnon, Bergel, Michael, Kleiman, Doron, Hefetz, Liron, Israeli, Hadar, Weksler-Zangen, Sarah, Agranovich, Bella, Abramovich, Ifat, Ben-Haroush Schyr, Rachel, Gottlieb, Eyal, Ben-Zvi, Danny
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21-07-2023; Elsevier
• Subjects: Omics; Surgery; Surgery; Omics
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2023.107046

Weight loss interventions, including dietary changes, pharmacotherapy, or bariatric surgery, prevent many of the adverse consequences of obesity, and may also confer intervention-specific benefits beyond those seen with decreased weight alone. We compared the molecular effects of different interventions on liver metabolism to understand the mechanisms underlying these benefits. Male rats on a high-fat, high-sucrose diet underwent sleeve gastrectomy (SG) or intermittent fasting with caloric restriction (IF-CR), achieving equivalent weight loss. The interventions were compared to ad-libitum (AL)-fed controls. Analysis of liver and blood metabolome and transcriptome revealed distinct and sometimes contrasting metabolic effects between the two interventions. SG primarily influenced one-carbon metabolic pathways, whereas IF-CR increased de novo lipogenesis and glycogen storage. These findings suggest that the unique metabolic pathways affected by SG and IF-CR contribute to their distinct clinical benefits, with bariatric surgery potentially influencing long-lasting changes through its effect on one-carbon metabolism.
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•Hepatic metabolism is affected differently by different weight loss interventions•Intermittent fasting results in increased lipogenesis and affects multiple pathways•Bariatric surgery uniquely affects one-carbon metabolic pathways and hepatic redox•Transmethylation cycle may be a promising target for treatment of metabolic disease
Surgery; Omics