Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm

Several pharmacological targets have been proposed as modulators of panic-like reactions. However, interest should be given to other potential therapeutic neurochemical agents. Recent attention has been given to the potential anxiolytic properties of cannabidiol, because of its complex actions on th...

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Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 37; no. 2; pp. 412 - 421
Main Authors:	URIBE-MARINO, Andres, FRANCISCO, Audrey, ANGELICA CASTIBLANCO-URBINA, Maria, TWARDOWSCHY, Andre, JOSE SALGADO-ROHNER, Carlos, CRIPPA, Jose Alexandre S, CECILIO HALLAK, Jaime Eduardo, WALDO ZUARDI, Antonio, CYSNE COIMBRA, Norberto
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-01-2012
Subjects:	Adult and adolescent clinical studies Animals Anti-Anxiety Agents - pharmacology Anti-Anxiety Agents - therapeutic use Anxiety disorders. Neuroses Biological and medical sciences Cannabidiol - pharmacology Cannabidiol - therapeutic use Disease Models, Animal Epicrates cenchria Fear - drug effects Humans Instinct Male Medical sciences Mice Original Panic attacks Panic disorder Panic Disorder - drug therapy Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Snakes Panic Anxiety disorder Emotion emotionality Cannabinoid Ophidia cannabidiol Fear Vertebrata endocannabinoid-mediated system Endogenous innate fear Endocannabinoid prey vs predator paradigm panic-related responses Panic attack Reptilia Models Drug of abuse Behavior
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Abstract	Several pharmacological targets have been proposed as modulators of panic-like reactions. However, interest should be given to other potential therapeutic neurochemical agents. Recent attention has been given to the potential anxiolytic properties of cannabidiol, because of its complex actions on the endocannabinoid system together with its effects on other neurotransmitter systems. The aim of this study was to investigate the effects of cannabidiol on innate fear-related behaviors evoked by a prey vs predator paradigm. Male Swiss mice were submitted to habituation in an arena containing a burrow and subsequently pre-treated with intraperitoneal administrations of vehicle or cannabidiol. A constrictor snake was placed inside the arena, and defensive and non-defensive behaviors were recorded. Cannabidiol caused a clear anti-aversive effect, decreasing explosive escape and defensive immobility behaviors outside and inside the burrow. These results show that cannabidiol modulates defensive behaviors evoked by the presence of threatening stimuli, even in a potentially safe environment following a fear response, suggesting a panicolytic effect.
AbstractList	Several pharmacological targets have been proposed as modulators of panic-like reactions. However, interest should be given to other potential therapeutic neurochemical agents. Recent attention has been given to the potential anxiolytic properties of cannabidiol, because of its complex actions on the endocannabinoid system together with its effects on other neurotransmitter systems. The aim of this study was to investigate the effects of cannabidiol on innate fear-related behaviors evoked by a prey vs predator paradigm. Male Swiss mice were submitted to habituation in an arena containing a burrow and subsequently pre-treated with intraperitoneal administrations of vehicle or cannabidiol. A constrictor snake was placed inside the arena, and defensive and non-defensive behaviors were recorded. Cannabidiol caused a clear anti-aversive effect, decreasing explosive escape and defensive immobility behaviors outside and inside the burrow. These results show that cannabidiol modulates defensive behaviors evoked by the presence of threatening stimuli, even in a potentially safe environment following a fear response, suggesting a panicolytic effect. Several pharmacological targets have been proposed as modulators of panic-like reactions. However, interest should be given to other potential therapeutic neurochemical agents. Recent attention has been given to the potential anxiolytic properties of cannabidiol, because of its complex actions on the endocannabinoid system together with its effects on other neurotransmitter systems. The aim of this study was to investigate the effects of cannabidiol on innate fear-related behaviors evoked by a prey vs predator paradigm. Male Swiss mice were submitted to habituation in an arena containing a burrow and subsequently pre-treated with intraperitoneal administrations of vehicle or cannabidiol. A constrictor snake was placed inside the arena, and defensive and non-defensive behaviors were recorded. Cannabidiol caused a clear anti-aversive effect, decreasing explosive escape and defensive immobility behaviors outside and inside the burrow. These results show that cannabidiol modulates defensive behaviors evoked by the presence of threatening stimuli, even in a potentially safe environment following a fear response, suggesting a panicolytic effect.
Author	FRANCISCO, Audrey ANGELICA CASTIBLANCO-URBINA, Maria TWARDOWSCHY, Andre CYSNE COIMBRA, Norberto CRIPPA, Jose Alexandre S JOSE SALGADO-ROHNER, Carlos URIBE-MARINO, Andres WALDO ZUARDI, Antonio CECILIO HALLAK, Jaime Eduardo
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Keywords	Panic Anxiety disorder Emotion emotionality Cannabinoid Ophidia cannabidiol Fear Vertebrata endocannabinoid-mediated system Endogenous innate fear Endocannabinoid prey vs predator paradigm panic-related responses Panic attack Reptilia Models Drug of abuse Behavior
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Snippet	Several pharmacological targets have been proposed as modulators of panic-like reactions. However, interest should be given to other potential therapeutic...
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SubjectTerms	Adult and adolescent clinical studies Animals Anti-Anxiety Agents - pharmacology Anti-Anxiety Agents - therapeutic use Anxiety disorders. Neuroses Biological and medical sciences Cannabidiol - pharmacology Cannabidiol - therapeutic use Disease Models, Animal Epicrates cenchria Fear - drug effects Humans Instinct Male Medical sciences Mice Original Panic attacks Panic disorder Panic Disorder - drug therapy Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Snakes
Title	Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm
URI	https://www.ncbi.nlm.nih.gov/pubmed/21918503 https://www.proquest.com/docview/910398627 https://search.proquest.com/docview/1008840700 https://search.proquest.com/docview/911936782 https://pubmed.ncbi.nlm.nih.gov/PMC3242302
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