Di-2-ethylhexylphthalate (DEHP) content of blood or blood components stored in plastic bags

Di-2-ethylhexylphthalate (DEHP) content of blood or blood components stored in plastic bags

Di-2-ethylhexylphthalate (DEHP) is a plasticizer used in the manufacture of plastic bags for blood products, which may be toxic. No more than a trace (less than 0.1 microgram/ml) could be detected in anticoagulants in blood bags, or in the blood of healthy untransfused subjects. A mean of 23 microgr...

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Bibliographic Details
Published in:Vox sanguinis Vol. 34; no. 2; p. 81
Main Authors: Sasakawa, S, Mitomi, Y
Format: Journal Article
Language:English
Published: England 01-02-1978
Subjects:
Anticoagulants
Blood Preservation
Chemical Phenomena
Chemistry
Citrates
Diethylhexyl Phthalate - analysis
Diethylhexyl Phthalate - blood
Humans
Phthalic Acids - blood
Plasma
Time Factors
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Description
Summary:Di-2-ethylhexylphthalate (DEHP) is a plasticizer used in the manufacture of plastic bags for blood products, which may be toxic. No more than a trace (less than 0.1 microgram/ml) could be detected in anticoagulants in blood bags, or in the blood of healthy untransfused subjects. A mean of 23 microgram/ml was found in ACD whole blood after 2 weeks storage, and 46 microgram/ml after 3 weeks; the corresponding figures for packed cells were 39 and 45 microgram/ml. The level in CPD whole blood was similar. Fresh frozen plasma and cryoprecipitate contained 7 microgram/ml, while levels of 1.0 and 0.7 microgram/ml of DEHP were found in the blood of two patients who had received massive transfusions. Most DEHP in stored blood was associated with plasma lipoproteins.
ISSN:0042-9007
DOI:10.1111/j.1423-0410.1978.tb03727.x