The L-form of N-7-mercaptoheptanoyl- O-phosphothreonine is the enantiomer active as component B in methyl-CoM reduction to methane

The reduction of methyl-CoM to methane in methanogenic bacteria is dependent on a low- M r, heat-stable compound designated component B, the structure of which has recently been assigned as N-7-mercaptoheptanoyl- O-phosphothreonine. We report here that only the enantiomer derived from O-phospho-L-th...

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Bibliographic Details
Published in:	FEBS letters Vol. 214; no. 2; pp. 265 - 268
Main Authors:	Kobelt, A., Pfaltz, A., Ankel-Fuchs, D., Thauer, R.K.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 20-04-1987 Elsevier
Subjects:	7-Mercaptoheptanoylthreonine phosphate Bacteriology Biological and medical sciences Component B Fundamental and applied biological sciences. Psychology Metabolism. Enzymes Methanobacterium thermoautotrophicum Methanogenic bacteria Methyl-CoM reductase Microbiology Component B Methyl-CoM reductase Methanogenic bacteria 7-Mercaptoheptanoylthreonine phosphate Enzyme Enantiomer Methanogenesis Bacteria Thermostable Catalyst activity Cofactor
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Summary:	The reduction of methyl-CoM to methane in methanogenic bacteria is dependent on a low- M r, heat-stable compound designated component B, the structure of which has recently been assigned as N-7-mercaptoheptanoyl- O-phosphothreonine. We report here that only the enantiomer derived from O-phospho-L-threonine has cofactor activity. N-7-Mercaptoheptanoyl- O-phospho-D-threonine was neither active nor inhibitory.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(87)80067-4