A New Meroterpene, A New Benzofuran Derivative and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Acremonium persicinum KUFA 1007 and Their Anticholinesterase Activities

• Published in: Marine drugs Vol. 17; no. 6; p. 379
• Main Authors: Alves, Ana J S, Pereira, José A, Dethoup, Tida, Cravo, Sara, Mistry, Sharad, Silva, Artur M S, Pinto, Madalena M M, Kijjoa, Anake
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25-06-2019; MDPI
• Subjects: Acetylcholinesterase; acremine S; acremine T; Acremonium - chemistry; Acremonium persicinum; Animals; anticholinesterase activities; Benzofuran; Benzofurans - chemistry; Carbon; Cholinesterase Inhibitors - chemistry; Circular dichroism; Circular Dichroism - methods; Dichroism; Ergosterol; Ergosterol - chemistry; Flavins - chemistry; Fungi; Hypocreaceae; Magnetic Resonance Spectroscopy - methods; Marine invertebrates; marine sponge-associated fungus; meroterpene; Metabolites; Microbial Sensitivity Tests - methods; NMR; Nuclear magnetic resonance; Porifera - microbiology; Spectra; Terpenes - chemistry; Two dimensional analysis; United States > US; Portugal; Gulf of Thailand; anticholinesterase activities; benzofuran; meroterpene; Hypocreaceae; marine sponge-associated fungus; acremine S; acremine T; Acremonium persicinum
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md17060379

Previously unreported meroterpene, acremine S (
), and benzopyran derivative, acremine T (
), were isolated, together with lumichrome (
), ergosterol (
) and ergosterol 5,8-endoperoxide, from cultures of the marine sponge-associated fungus
KUF1007. The structure of the previously unreported compounds was established based on an extensive analysis of 1D and 2D NMR spectra as well as HRMS data. The absolute configurations of the stereogenic centers of
were established, unambiguously, based on NOESY correlations and comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Compounds
were tested for their
acetylcholinesterase and butyrylcholinesterase inhibitory activities.