Natural killer cell phenotype and clinical response to interferon-beta therapy in multiple sclerosis

• Published in: Clinical immunology (Orlando, Fla.) Vol. 141; no. 3; pp. 348 - 356
• Main Authors: Martínez-Rodríguez, J.E, López-Botet, M, Munteis, E, Rio, J, Roquer, J, Montalban, X, Comabella, M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01-12-2011; Elsevier
• Subjects: Adult; Allergy and Immunology; Biological and medical sciences; Case-Control Studies; CD56; CD56 Antigen - immunology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunologic Factors - immunology; Immunologic Factors - therapeutic use; Interferon-beta; Interferon-beta - immunology; Interferon-beta - therapeutic use; Killer Cells, Natural - immunology; KIR; LILRB1; Male; Medical sciences; Middle Aged; Multiple sclerosis; Multiple Sclerosis - drug therapy; Multiple Sclerosis - immunology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Natural killer receptors; Neurology; Receptors, Natural Killer Cell - immunology; Multiple sclerosis; LILRB1; Natural killer receptors; Interferon-beta; KIR; CD56; Nervous system diseases; Neural cell adhesion molecule; Killer immunoglobulin like receptor; Cytokine; Inflammatory disease; Natural killer cell; Phenotype; Immunology; Treatment; Inhibitory receptor LILRB1; Central nervous system disease; Beta interferon; T-Lymphocyte; Biological receptor
• ISSN: 1521-6616; 1521-7035
• DOI: 10.1016/j.clim.2011.09.006

Abstract CD56bright NK cells, which may play a role in immunoregulation, are expanded in multiple sclerosis (MS) patients treated with immunomodulatory therapies such as daclizumab and interferon-beta (IFNβ). Yet, whether this NK cell subset is directly involved in the therapeutic effect is unknown. As NK receptor (NKR) expression by subsets of NK cells and CD8+ T lymphocytes is related to MS clinical course, we addressed whether CD56bright NK cells and NKR in IFNβ-treated MS patients differ according to the clinical response. IFNβ was associated to lower LILRB1+ and KIR + NK cells, and higher NKG2A + NK cell proportions, an immunophenotypic pattern mainly found in responders. After IFNβ treatment, a CD56bright NK cell expansion was significantly related to a positive clinical response. Our results reveal that IFNβ may promote in responders changes in the NK cell immunophenotype, corresponding to the profile found at early maturation stages of this lymphocyte lineage.