The Host Immune Response to Scedosporium / Lomentospora

• Published in: Journal of fungi (Basel) Vol. 7; no. 2; p. 75
• Main Authors: Buldain, Idoia, Martin-Souto, Leire, Antoran, Aitziber, Areitio, Maialen, Aparicio-Fernandez, Leire, Rementeria, Aitor, Hernando, Fernando L, Ramirez-Garcia, Andoni
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22-01-2021; MDPI
• Subjects: Adapter proteins; Antifungal activity; Antifungal agents; Antigens; Catalase; Cell walls; cytokine; Cytokines; Epithelial cells; Fungal infections; Fungi; Glucans; Hsp70 protein; Immune response; Insects; Kinases; Lectins; Lomentospora; lymphocyte; macrophage; Microglial cells; Microorganisms; Mortality; Opportunist infection; Pathogens; Phagocytes; Review; Scedosporium; Signal transduction; TLR2 protein; TLR4 protein; Toll-like receptors; cytokine; Lomentospora; immune response; macrophage; monocyte; epithelium; antigen; Scedosporium; lymphocyte
• ISSN: 2309-608X; 2309-608X
• DOI: 10.3390/jof7020075

Infections caused by the opportunistic pathogens
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are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them.
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cell wall components, including peptidorhamnomannans (PRMs), α-glucans and glucosylceramides, are important immune response activators following their recognition by TLR2, TLR4 and Dectin-1 and through receptors that are yet unknown. After recognition, cytokine synthesis and antifungal activity of different phagocytes and epithelial cells is species-specific, highlighting the poor response by microglial cells against
. Moreover, a great number of
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antigens have been identified, most notably catalase, PRM and Hsp70 for their potential medical applicability. Against host immune response, these fungi contain evasion mechanisms, inducing host non-protective response, masking fungal molecular patterns, destructing host defense proteins and decreasing oxidative killing. In conclusion, although many advances have been made, many aspects remain to be elucidated and more research is necessary to shed light on the immune response to
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.