Dietary n -6/ n -3 Ratio Influences Brain Fatty Acid Composition in Adult Rats

Dietary n -6/ n -3 Ratio Influences Brain Fatty Acid Composition in Adult Rats

There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in -6/ -3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to vari...

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Published in:Nutrients Vol. 12; no. 6; p. 1847
Main Authors: Horman, Thomas, Fernandes, Maria F, Tache, Maria C, Hucik, Barbora, Mutch, David M, Leri, Francesco
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 21-06-2020
MDPI
Subjects:
alpha-Linolenic Acid - metabolism
Animal cognition
Animals
Brain
Brain - metabolism
Brain Diseases - metabolism
Brain Mapping
Composition
Diet
Diet, High-Fat
Dietary Fats - metabolism
Fatty acid composition
Fatty acids
Fatty Acids - metabolism
Fatty Acids, Monounsaturated - metabolism
Fatty Acids, Omega-3 - metabolism
Fatty Acids, Omega-6 - metabolism
Feeding Behavior
High fat diet
Hippocampus
Hypothalamus
Linoleic acid
Linoleic Acid - metabolism
Linolenic acid
Male
Mental depression
Mental health
Nutritional Status
polyunsaturated fatty acids
Prefrontal cortex
Psychopathology
rat
Ratios
Rats, Sprague-Dawley
Trends
α-linolenic acid
Canada
United States > US
linoleic acid
diet
rat
brain
α-linolenic acid
polyunsaturated fatty acids
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Abstract There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in -6/ -3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to various psychopathologies. Adult male Sprague Dawley rats consumed isocaloric diets (35% kcal from fat) containing different ratios of linoleic acid ( -6) and alpha-linolenic acid ( -3) for 2 months. It was found that the profiles of PUFA in the prefrontal cortex, hippocampus, and hypothalamus reflected the fatty acid composition of the diet. In addition, region-specific changes in saturated fatty acids and monounsaturated fatty acids were detected in the hypothalamus, but not in the hippocampus or prefrontal cortex. This study in adult rats demonstrates that fatty acid remodeling in the brain by diet can occur within months and provides additional evidence for the suggestion that diet could impact mental health.
AbstractList There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in n-6/n-3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to various psychopathologies. Adult male Sprague Dawley rats consumed isocaloric diets (35% kcal from fat) containing different ratios of linoleic acid (n-6) and alpha-linolenic acid (n-3) for 2 months. It was found that the profiles of PUFA in the prefrontal cortex, hippocampus, and hypothalamus reflected the fatty acid composition of the diet. In addition, region-specific changes in saturated fatty acids and monounsaturated fatty acids were detected in the hypothalamus, but not in the hippocampus or prefrontal cortex. This study in adult rats demonstrates that fatty acid remodeling in the brain by diet can occur within months and provides additional evidence for the suggestion that diet could impact mental health.
There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in n -6/ n -3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to various psychopathologies. Adult male Sprague Dawley rats consumed isocaloric diets (35% kcal from fat) containing different ratios of linoleic acid ( n -6) and alpha-linolenic acid ( n -3) for 2 months. It was found that the profiles of PUFA in the prefrontal cortex, hippocampus, and hypothalamus reflected the fatty acid composition of the diet. In addition, region-specific changes in saturated fatty acids and monounsaturated fatty acids were detected in the hypothalamus, but not in the hippocampus or prefrontal cortex. This study in adult rats demonstrates that fatty acid remodeling in the brain by diet can occur within months and provides additional evidence for the suggestion that diet could impact mental health.
There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in -6/ -3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to various psychopathologies. Adult male Sprague Dawley rats consumed isocaloric diets (35% kcal from fat) containing different ratios of linoleic acid ( -6) and alpha-linolenic acid ( -3) for 2 months. It was found that the profiles of PUFA in the prefrontal cortex, hippocampus, and hypothalamus reflected the fatty acid composition of the diet. In addition, region-specific changes in saturated fatty acids and monounsaturated fatty acids were detected in the hypothalamus, but not in the hippocampus or prefrontal cortex. This study in adult rats demonstrates that fatty acid remodeling in the brain by diet can occur within months and provides additional evidence for the suggestion that diet could impact mental health.
Author Horman, Thomas
Fernandes, Maria F
Hucik, Barbora
Mutch, David M
Tache, Maria C
Leri, Francesco
AuthorAffiliation 1 Department of Psychology and Neuroscience, University of Guelph, Guelph, ON N1G 2W1, Canada; thorman@uoguelph.ca (T.H.); mariafer@uoguelph.ca (M.F.F.)
2 Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada; mariacristinatache@gmail.com (M.C.T.); bhucik@uoguelph.ca (B.H.); dmutch@uoguelph.ca (D.M.M.)
AuthorAffiliation_xml – name: 1 Department of Psychology and Neuroscience, University of Guelph, Guelph, ON N1G 2W1, Canada; thorman@uoguelph.ca (T.H.); mariafer@uoguelph.ca (M.F.F.)
– name: 2 Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada; mariacristinatache@gmail.com (M.C.T.); bhucik@uoguelph.ca (B.H.); dmutch@uoguelph.ca (D.M.M.)
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  givenname: Maria F
  orcidid: 0000-0001-8368-3481
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  fullname: Fernandes, Maria F
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– sequence: 4
  givenname: Barbora
  surname: Hucik
  fullname: Hucik, Barbora
  organization: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
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  givenname: David M
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– sequence: 6
  givenname: Francesco
  surname: Leri
  fullname: Leri, Francesco
  organization: Department of Psychology and Neuroscience, University of Guelph, Guelph, ON N1G 2W1, Canada
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32575852$$D View this record in MEDLINE/PubMed
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Issue 6
Keywords linoleic acid
diet
rat
brain
α-linolenic acid
polyunsaturated fatty acids
Language English
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Snippet There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated...
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SubjectTerms alpha-Linolenic Acid - metabolism
Animal cognition
Animals
Brain
Brain - metabolism
Brain Diseases - metabolism
Brain Mapping
Composition
Diet
Diet, High-Fat
Dietary Fats - metabolism
Fatty acid composition
Fatty acids
Fatty Acids - metabolism
Fatty Acids, Monounsaturated - metabolism
Fatty Acids, Omega-3 - metabolism
Fatty Acids, Omega-6 - metabolism
Feeding Behavior
High fat diet
Hippocampus
Hypothalamus
Linoleic acid
Linoleic Acid - metabolism
Linolenic acid
Male
Mental depression
Mental health
Nutritional Status
polyunsaturated fatty acids
Prefrontal cortex
Psychopathology
rat
Ratios
Rats, Sprague-Dawley
Trends
α-linolenic acid
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Title Dietary n -6/ n -3 Ratio Influences Brain Fatty Acid Composition in Adult Rats
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