Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

The presence of β-glucans and phenolic compounds in suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tes...

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Published in:Nutrients Vol. 11; no. 11; p. 2720
Main Authors: Laurino, Leticia F, Viroel, Fabia J M, Caetano, Erika, Spim, Sara, Pickler, Thaisa B, Rosa-Castro, Raquel M, Vasconcelos, Edilma Albuquerque, Jozala, Angela F, Hataka, Alessandre, Grotto, Denise, Gerenutti, Marli
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 09-11-2019
MDPI
Subjects:
Animals
anti-diabetic activity
Antidiabetics
Antioxidants
Biological Products - pharmacology
Blood Glucose - drug effects
Complications
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental
Diabetes, Gestational - metabolism
Diet
Embryos
Experiments
Fasting
Female
Fetus - drug effects
Fetuses
Free radicals
Functional Food
Functional foods & nutraceuticals
Gene expression
Gestational diabetes
gestational diabetes mellitus
Glucose
Glycosylation
Hydrogen peroxide
Hyperglycemia
Hypoglycemic Agents - pharmacology
Implantation
Insulin resistance
lentinus edodes
Maternal Exposure
Metabolism
mushroom nutraceuticals
Mushrooms
Nitric oxide
Oxidation
Oxidative stress
Oxidative Stress - drug effects
Pancreas
Placenta
pre-clinical study
Pregnancy
Rats
Rats, Wistar
Response time
Shiitake Mushrooms
Transplants & implants
Veterinary medicine
Brazil
mushroom nutraceuticals
gestational diabetes mellitus
pre-clinical study
anti-diabetic activity
Lentinus edodes
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Abstract The presence of β-glucans and phenolic compounds in suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.
AbstractList Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.
Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.
BACKGROUNDThe presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. METHODSOn the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. RESULTSThe mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. CONCLUSIONSLentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.
The presence of β-glucans and phenolic compounds in suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.
The glucose oxidation and the glycation of non-enzymatic proteins, associated with the increase of oxygen free radicals, favor the development of diabetic complications in pregnant women. [...]exogenous antioxidant agents such as functional foods are useful to prevent and treat DM-STZ [33,34]. [...]in diabetic rats, there were no reduction in response time or blood glucose levels, which were increased in all studied periods when compared to the control group [38,39]. GDM + Leb promoted an increase in skull and tail parameters when compared to GDM + S, indicating a protective effect of the mushroom when administered before STZ. [...]Lentinus edodes mushroom was able to protect the animals from the post-implantation losses of the embryo when administered before the GDM-STZ induction. STZ stimulates the generation of H2O2 in β-pancreatic cells that are destroyed by the production of nitrogen monoxide (NO) [62]. [...]oxidative stress occurs even in normal pregnancies due to the high metabolic activity of the placenta and maternal metabolism [63].
Author Spim, Sara
Jozala, Angela F
Rosa-Castro, Raquel M
Grotto, Denise
Gerenutti, Marli
Hataka, Alessandre
Laurino, Leticia F
Vasconcelos, Edilma Albuquerque
Viroel, Fabia J M
Caetano, Erika
Pickler, Thaisa B
AuthorAffiliation 1 University of Sorocaba, Sorocaba-SP 18023-000, Brazil; leticia_fl_@hotmail.com (L.F.L.); fabia.viroel@prof.uniso.br (F.J.M.V.); erikacaetano01@hotmail.com (E.C.); sara.spim@edu.uniso.br (S.S.); thaisa.pickler@uniso.br (T.B.P.); raquel.rosa@prof.uniso.br (R.M.R.-C.); edilma.vasconcelos@prof.uniso.br (E.A.V.); angela.jozala@prof.uniso.br (A.F.J.); marli.gerenutti@gmail.com (M.G.)
2 Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo 18610-307, Brazil
AuthorAffiliation_xml – name: 2 Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo 18610-307, Brazil
– name: 1 University of Sorocaba, Sorocaba-SP 18023-000, Brazil; leticia_fl_@hotmail.com (L.F.L.); fabia.viroel@prof.uniso.br (F.J.M.V.); erikacaetano01@hotmail.com (E.C.); sara.spim@edu.uniso.br (S.S.); thaisa.pickler@uniso.br (T.B.P.); raquel.rosa@prof.uniso.br (R.M.R.-C.); edilma.vasconcelos@prof.uniso.br (E.A.V.); angela.jozala@prof.uniso.br (A.F.J.); marli.gerenutti@gmail.com (M.G.)
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Issue 11
Keywords mushroom nutraceuticals
gestational diabetes mellitus
pre-clinical study
anti-diabetic activity
Lentinus edodes
Language English
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Snippet The presence of β-glucans and phenolic compounds in suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and...
Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational...
The glucose oxidation and the glycation of non-enzymatic proteins, associated with the increase of oxygen free radicals, favor the development of diabetic...
BACKGROUNDThe presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational...
Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational...
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pubmedcentral
proquest
crossref
pubmed
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Open Access Repository
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Index Database
StartPage 2720
SubjectTerms Animals
anti-diabetic activity
Antidiabetics
Antioxidants
Biological Products - pharmacology
Blood Glucose - drug effects
Complications
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental
Diabetes, Gestational - metabolism
Diet
Embryos
Experiments
Fasting
Female
Fetus - drug effects
Fetuses
Free radicals
Functional Food
Functional foods & nutraceuticals
Gene expression
Gestational diabetes
gestational diabetes mellitus
Glucose
Glycosylation
Hydrogen peroxide
Hyperglycemia
Hypoglycemic Agents - pharmacology
Implantation
Insulin resistance
lentinus edodes
Maternal Exposure
Metabolism
mushroom nutraceuticals
Mushrooms
Nitric oxide
Oxidation
Oxidative stress
Oxidative Stress - drug effects
Pancreas
Placenta
pre-clinical study
Pregnancy
Rats
Rats, Wistar
Response time
Shiitake Mushrooms
Transplants & implants
Veterinary medicine
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Title Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus
URI https://www.ncbi.nlm.nih.gov/pubmed/31717560
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https://search.proquest.com/docview/2314249434
https://pubmed.ncbi.nlm.nih.gov/PMC6893821
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