Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

• Published in: Nutrients Vol. 11; no. 11; p. 2720
• Main Authors: Laurino, Leticia F, Viroel, Fabia J M, Caetano, Erika, Spim, Sara, Pickler, Thaisa B, Rosa-Castro, Raquel M, Vasconcelos, Edilma Albuquerque, Jozala, Angela F, Hataka, Alessandre, Grotto, Denise, Gerenutti, Marli
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09-11-2019; MDPI
• Subjects: Animals; anti-diabetic activity; Antidiabetics; Antioxidants; Biological Products - pharmacology; Blood Glucose - drug effects; Complications; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental; Diabetes, Gestational - metabolism; Diet; Embryos; Experiments; Fasting; Female; Fetus - drug effects; Fetuses; Free radicals; Functional Food; Functional foods & nutraceuticals; Gene expression; Gestational diabetes; gestational diabetes mellitus; Glucose; Glycosylation; Hydrogen peroxide; Hyperglycemia; Hypoglycemic Agents - pharmacology; Implantation; Insulin resistance; lentinus edodes; Maternal Exposure; Metabolism; mushroom nutraceuticals; Mushrooms; Nitric oxide; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Pancreas; Placenta; pre-clinical study; Pregnancy; Rats; Rats, Wistar; Response time; Shiitake Mushrooms; Transplants & implants; Veterinary medicine; Brazil; mushroom nutraceuticals; gestational diabetes mellitus; pre-clinical study; anti-diabetic activity; Lentinus edodes
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11112720

The presence of β-glucans and phenolic compounds in
suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and
exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests.
On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation.
The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups.
mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.