Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus

Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not cause...

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Bibliographic Details
Published in:	Biochemistry (Moscow) Vol. 77; no. 10; pp. 1172 - 1180
Main Authors:	Korovina, A. N., Tunitskaya, V. L., Khomutov, M. A., Simonian, A. R., Khomutov, A. R., Ivanov, A. V., Kochetkov, S. N.
Format:	Journal Article
Language:	English
Published:	Dordrecht SP MAIK Nauka/Interperiodica 01-10-2012 Springer Springer Nature B.V
Subjects:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Enzyme Activation - drug effects Enzymes Genomics Hepacivirus - drug effects Hepacivirus - enzymology Hepatitis Hepatitis C virus Humans Life Sciences Microbiology Polyamines Putrescine - analogs & derivatives Putrescine - pharmacology RNA RNA Helicases - antagonists & inhibitors RNA Helicases - metabolism RNA polymerase RNA-Dependent RNA Polymerase - chemistry RNA-Dependent RNA Polymerase - metabolism Spermidine - analogs & derivatives Spermidine - pharmacology Spermine - analogs & derivatives Spermine - pharmacology Viral Nonstructural Proteins - drug effects spermidine analogs hepatitis C virus spermine RNA polymerase helicase polyamines
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