Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus
Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not cause...
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| Published in: | Biochemistry (Moscow) Vol. 77; no. 10; pp. 1172 - 1180 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-10-2012
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| Abstract | Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not caused by the stabilization of the enzyme or by competition with template-primer complex, but rather it was due to achievement of true maximum velocity
V
max
. Natural polyamines and their derivatives effectively inhibited the helicase reaction catalyzed by another enzyme of HCV replication — helicase/NTPase (NS3 protein). However, these compounds affected neither the NTPase reaction nor its activation by polynucleotides. Activation of the HCV RNA polymerase and inhibition of the viral helicase were shown at physiological concentrations of the polyamines. These data suggest that biogenic polyamines may cause differently directed effects on the replication of the HCV genome in an infected cell. |
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| AbstractList | Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not caused by the stabilization of the enzyme or by competition with template--primer complex, but rather it was due to achievement of true maximum velocity [V.sub.max]. Natural polyamines and their derivatives effectively inhibited the helicase reaction catalyzed by another enzyme of HCV replication--helicase/NTPase (NS3 protein). However, these compounds affected neither the NTPase reaction nor its activation by polynucleotides. Activation of the HCV RNA polymerase and inhibition of the viral helicase were shown at physiological concentrations of the polyamines. These data suggest that biogenic polyamines may cause differently directed effects on the replication of the HCV genome in an infected cell. DOI: 10.1134/S0006297912100094 Key words: polyamines, spermine, spermidine, analogs, hepatitis C virus, RNA polymerase, helicase Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not caused by the stabilization of the enzyme or by competition with template-primer complex, but rather it was due to achievement of true maximum velocity V max . Natural polyamines and their derivatives effectively inhibited the helicase reaction catalyzed by another enzyme of HCV replication — helicase/NTPase (NS3 protein). However, these compounds affected neither the NTPase reaction nor its activation by polynucleotides. Activation of the HCV RNA polymerase and inhibition of the viral helicase were shown at physiological concentrations of the polyamines. These data suggest that biogenic polyamines may cause differently directed effects on the replication of the HCV genome in an infected cell. Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not caused by the stabilization of the enzyme or by competition with template-primer complex, but rather it was due to achievement of true maximum velocity V sub(max). Natural polyamines and their derivatives effectively inhibited the helicase reaction catalyzed by another enzyme of HCV replication - helicase/NTPase (NS3 protein). However, these compounds affected neither the NTPase reaction nor its activation by polynucleotides. Activation of the HCV RNA polymerase and inhibition of the viral helicase were shown at physiological concentrations of the polyamines. These data suggest that biogenic polyamines may cause differently directed effects on the replication of the HCV genome in an infected cell. Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not caused by the stabilization of the enzyme or by competition with template-primer complex, but rather it was due to achievement of true maximum velocity V(max). Natural polyamines and their derivatives effectively inhibited the helicase reaction catalyzed by another enzyme of HCV replication - helicase/NTPase (NS3 protein). However, these compounds affected neither the NTPase reaction nor its activation by polynucleotides. Activation of the HCV RNA polymerase and inhibition of the viral helicase were shown at physiological concentrations of the polyamines. These data suggest that biogenic polyamines may cause differently directed effects on the replication of the HCV genome in an infected cell. Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV) was investigated. It was found that spermine and spermidine activate HCV RNA-dependent RNA polymerase (NS5B protein). This effect was not caused by the stabilization of the enzyme or by competition with template-primer complex, but rather it was due to achievement of true maximum velocity V ^sub max^. Natural polyamines and their derivatives effectively inhibited the helicase reaction catalyzed by another enzyme of HCV replication -- helicase/NTPase (NS3 protein). However, these compounds affected neither the NTPase reaction nor its activation by polynucleotides. Activation of the HCV RNA polymerase and inhibition of the viral helicase were shown at physiological concentrations of the polyamines. These data suggest that biogenic polyamines may cause differently directed effects on the replication of the HCV genome in an infected cell.[PUBLICATION ABSTRACT] |
| Audience | Academic |
| Author | Korovina, A. N. Ivanov, A. V. Kochetkov, S. N. Khomutov, A. R. Tunitskaya, V. L. Simonian, A. R. Khomutov, M. A. |
| Author_xml | – sequence: 1 givenname: A. N. surname: Korovina fullname: Korovina, A. N. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 2 givenname: V. L. surname: Tunitskaya fullname: Tunitskaya, V. L. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 3 givenname: M. A. surname: Khomutov fullname: Khomutov, M. A. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 4 givenname: A. R. surname: Simonian fullname: Simonian, A. R. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 5 givenname: A. R. surname: Khomutov fullname: Khomutov, A. R. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 6 givenname: A. V. surname: Ivanov fullname: Ivanov, A. V. email: aivanov@yandex.ru, aivanov@eimb.ru organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 7 givenname: S. N. surname: Kochetkov fullname: Kochetkov, S. N. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23157297$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00726_013_1587_9 crossref_primary_10_3390_biom10040628 crossref_primary_10_1016_j_bmcl_2019_01_008 crossref_primary_10_1007_s00436_018_5821_y crossref_primary_10_1134_S0026893317030128 crossref_primary_10_1016_j_bbrc_2017_01_032 crossref_primary_10_2147_IDR_S262024 crossref_primary_10_3390_cells13121036 |
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| Title | Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus |
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