The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 25; no. 2; pp. 133 - 137
• Main Authors: La Merrill, Michele, Torres-Sánchez, Luisa, Ruiz-Ramos, Rubén, López-Carrillo, Lizbeth, Cebrián, Mariano E., Chen, Jia
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01-02-2012; Taylor & Francis
• Subjects: Adult; DNA Methylation; epigenetics; Female; Genetic Variation; Genotype; Humans; Maternal Age; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; micronutrient deficiency; Micronutrients - deficiency; MTHFR 677; Nutritional Status; one carbon metabolism; Pregnancy - metabolism; Pregnancy Trimester, First; Vitamin B6; Young Adult
• ISSN: 1476-7058; 1476-4954
• DOI: 10.3109/14767058.2011.564242

Objective. Our aim was to evaluate possible associations between consumption of micronutrients involved in one-carbon metabolism, MTHFR genotypes, and global DNA methylation in pregnant women.
Methods. A semi-quantitative dietary questionnaire was administered to 195 women during their first trimester in Morelos, Mexico. Two functional polymorphisms of the key folate-metabolizing gene, i.e. MTHFR 677 C>T and 1298 A>C, as well as global DNA methylation were assessed in peripheral blood drawn during the interview.
Results. Independent of maternal age and caloric intake, vitamin B6 deficiency was associated with 1.8 fold increased risk of hypomethylation in women carrying the MTHFR 677 T allele.
Conclusions. There exists a subpopulation that is more susceptible to B vitamin deficiencies.