Immunisation of cattle with a recombinant togavirus-vaccinia virus strain

Genetic engineering techniques have been used to construct a vaccinia virus recombinant which contains and expresses togavirus (Sindbis) genetic information. Intradermal inoculation of this recombinant strain into calves caused a transient pock-type lesion at the site of inoculation and elicited the...

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Bibliographic Details
Published in:	Research in veterinary science Vol. 39; no. 1; p. 113
Main Authors:	Franke, C A, Berry, E S, Smith, A W, Hruby, D E
Format:	Journal Article
Language:	English
Published:	England 01-07-1985
Subjects:	Animals Antibodies, Viral - biosynthesis Cattle - immunology Genetic Engineering Injections, Intradermal - veterinary Recombination, Genetic Sindbis Virus - genetics Sindbis Virus - immunology Vaccinia virus - genetics Vaccinia virus - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology
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Summary:	Genetic engineering techniques have been used to construct a vaccinia virus recombinant which contains and expresses togavirus (Sindbis) genetic information. Intradermal inoculation of this recombinant strain into calves caused a transient pock-type lesion at the site of inoculation and elicited the production of substantial levels of anti-Sindbis virus neutralising antibodies. These results suggest that recombinant vaccinia virus vaccines may have potential for use in veterinary medicine.
ISSN:	0034-5288
DOI:	10.1016/S0034-5288(18)31784-3