Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow under conditions when the classical respiratory ch...

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Bibliographic Details
Published in:	Disease models & mechanisms Vol. 10; no. 2; pp. 163 - 171
Main Authors:	Szibor, Marten, Dhandapani, Praveen K, Dufour, Eric, Holmström, Kira M, Zhuang, Yuan, Salwig, Isabelle, Wittig, Ilka, Heidler, Juliana, Gizatullina, Zemfira, Gainutdinov, Timur, Fuchs, Helmut, Gailus-Durner, Valérie, de Angelis, Martin Hrabě, Nandania, Jatin, Velagapudi, Vidya, Wietelmann, Astrid, Rustin, Pierre, Gellerich, Frank N, Jacobs, Howard T, Braun, Thomas
Format:	Journal Article
Language:	English
Published:	England The Company of Biologists Ltd 01-02-2017 The Company of Biologists
Subjects:	Alternative oxidase Animals Ciona intestinalis - enzymology Cyanides - administration & dosage Cyanides - toxicity Enzymes Heart Histology Males Mice, Transgenic Mitochondria Mitochondria - metabolism Mitochondrial disease Mitochondrial Proteins - metabolism Molecular weight Musculoskeletal system Neurodegeneration Oxidoreductases - metabolism Pathophysiology Physiological Phenomena Plant Proteins - metabolism Protective Agents - metabolism Proteins Respiratory chain RNA, Untranslated - genetics Stem cells Mitochondria Respiratory chain Alternative oxidase Mitochondrial disease
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