A High-Throughput Phenotypic Screen of the 'Pandemic Response Box' Identifies a Quinoline Derivative with Significant Anthelmintic Activity
Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including , are particularly important. The excessive use of anthelmintic compounds to treat infections and disease has led to widespread resi...
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| Published in: | Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 2; p. 257 |
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| Main Authors: | , , , , , , , , , |
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| Abstract | Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including
, are particularly important. The excessive use of anthelmintic compounds to treat infections and disease has led to widespread resistance to these compounds in nematodes, such that there is a need for new anthelmintics with distinctive mechanisms of action. With a focus on discovering new anthelmintic entities, we screened 400 chemically diverse compounds within the '
' (from Medicines for Malaria Venture, MMV) for activity against
and its free-living relative,
-a model organism. Using established phenotypic assays, test compounds were evaluated in vitro for their ability to inhibit the motility and/or development of
and
. Dose-response evaluations identified a compound, MMV1581032, that significantly the motility of
larvae (IC
= 3.4 ± 1.1 μM) and young adults of
(IC
= 7.1 ± 4.6 μM), and the development of
larvae (IC
= 2.2 ± 0.7 μM). The favourable characteristics of MMV1581032, such as suitable physicochemical properties and an efficient, cost-effective pathway to analogue synthesis, indicates a promising candidate for further evaluation as a nematocide. Future work will focus on a structure-activity relationship investigation of this chemical scaffold, a toxicity assessment of potent analogues and a mechanism/mode of action investigation. |
|---|---|
| AbstractList | Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including
, are particularly important. The excessive use of anthelmintic compounds to treat infections and disease has led to widespread resistance to these compounds in nematodes, such that there is a need for new anthelmintics with distinctive mechanisms of action. With a focus on discovering new anthelmintic entities, we screened 400 chemically diverse compounds within the '
' (from Medicines for Malaria Venture, MMV) for activity against
and its free-living relative,
-a model organism. Using established phenotypic assays, test compounds were evaluated in vitro for their ability to inhibit the motility and/or development of
and
. Dose-response evaluations identified a compound, MMV1581032, that significantly the motility of
larvae (IC
= 3.4 ± 1.1 μM) and young adults of
(IC
= 7.1 ± 4.6 μM), and the development of
larvae (IC
= 2.2 ± 0.7 μM). The favourable characteristics of MMV1581032, such as suitable physicochemical properties and an efficient, cost-effective pathway to analogue synthesis, indicates a promising candidate for further evaluation as a nematocide. Future work will focus on a structure-activity relationship investigation of this chemical scaffold, a toxicity assessment of potent analogues and a mechanism/mode of action investigation. Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus contortus, are particularly important. The excessive use of anthelmintic compounds to treat infections and disease has led to widespread resistance to these compounds in nematodes, such that there is a need for new anthelmintics with distinctive mechanisms of action. With a focus on discovering new anthelmintic entities, we screened 400 chemically diverse compounds within the ‘Pandemic Response Box’ (from Medicines for Malaria Venture, MMV) for activity against H. contortus and its free-living relative, Caenorhabditis elegans—a model organism. Using established phenotypic assays, test compounds were evaluated in vitro for their ability to inhibit the motility and/or development of H. contortus and C. elegans. Dose-response evaluations identified a compound, MMV1581032, that significantly the motility of H. contortus larvae (IC50 = 3.4 ± 1.1 μM) and young adults of C. elegans (IC50 = 7.1 ± 4.6 μM), and the development of H. contortus larvae (IC50 = 2.2 ± 0.7 μM). The favourable characteristics of MMV1581032, such as suitable physicochemical properties and an efficient, cost-effective pathway to analogue synthesis, indicates a promising candidate for further evaluation as a nematocide. Future work will focus on a structure-activity relationship investigation of this chemical scaffold, a toxicity assessment of potent analogues and a mechanism/mode of action investigation. Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus contortus , are particularly important. The excessive use of anthelmintic compounds to treat infections and disease has led to widespread resistance to these compounds in nematodes, such that there is a need for new anthelmintics with distinctive mechanisms of action. With a focus on discovering new anthelmintic entities, we screened 400 chemically diverse compounds within the ‘ Pandemic Response Box ’ (from Medicines for Malaria Venture, MMV) for activity against H. contortus and its free-living relative, Caenorhabditis elegans —a model organism. Using established phenotypic assays, test compounds were evaluated in vitro for their ability to inhibit the motility and/or development of H. contortus and C. elegans . Dose-response evaluations identified a compound, MMV1581032, that significantly the motility of H. contortus larvae (IC 50 = 3.4 ± 1.1 μM) and young adults of C. elegans (IC 50 = 7.1 ± 4.6 μM), and the development of H. contortus larvae (IC 50 = 2.2 ± 0.7 μM). The favourable characteristics of MMV1581032, such as suitable physicochemical properties and an efficient, cost-effective pathway to analogue synthesis, indicates a promising candidate for further evaluation as a nematocide. Future work will focus on a structure-activity relationship investigation of this chemical scaffold, a toxicity assessment of potent analogues and a mechanism/mode of action investigation. |
| Author | Taki, Aya C Jabbar, Abdul Gasser, Robin B Byrne, Joseph J Samby, Kirandeep Shanley, Harrison T Nguyen, Nghi Wells, Tim N C Sleebs, Brad E Boag, Peter R |
| AuthorAffiliation | 3 Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; peter.boag@monash.edu 4 Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; nguyen.n@wehi.edu.au (N.N.); sleebs@wehi.edu.au (B.E.S.) 2 Medicines for Malaria Venture (MMV), 1215 Geneva, Switzerland; wellst@mmv.org (T.N.C.W.); sambyk-consultants@mmv.org (K.S.) 1 Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia; hshanley@student.unimelb.edu.au (H.T.S.); aya.taki@unimelb.edu.au (A.C.T.); byrnej1@unimelb.edu.au (J.J.B.); jabbara@unimelb.edu.au (A.J.) |
| AuthorAffiliation_xml | – name: 2 Medicines for Malaria Venture (MMV), 1215 Geneva, Switzerland; wellst@mmv.org (T.N.C.W.); sambyk-consultants@mmv.org (K.S.) – name: 3 Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; peter.boag@monash.edu – name: 4 Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; nguyen.n@wehi.edu.au (N.N.); sleebs@wehi.edu.au (B.E.S.) – name: 1 Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia; hshanley@student.unimelb.edu.au (H.T.S.); aya.taki@unimelb.edu.au (A.C.T.); byrnej1@unimelb.edu.au (J.J.B.); jabbara@unimelb.edu.au (A.J.) |
| Author_xml | – sequence: 1 givenname: Harrison T orcidid: 0000-0001-6471-9581 surname: Shanley fullname: Shanley, Harrison T organization: Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia – sequence: 2 givenname: Aya C orcidid: 0000-0003-3489-4367 surname: Taki fullname: Taki, Aya C organization: Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia – sequence: 3 givenname: Joseph J surname: Byrne fullname: Byrne, Joseph J organization: Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia – sequence: 4 givenname: Abdul orcidid: 0000-0001-8888-0046 surname: Jabbar fullname: Jabbar, Abdul organization: Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia – sequence: 5 givenname: Tim N C surname: Wells fullname: Wells, Tim N C organization: Medicines for Malaria Venture (MMV), 1215 Geneva, Switzerland – sequence: 6 givenname: Kirandeep surname: Samby fullname: Samby, Kirandeep organization: Medicines for Malaria Venture (MMV), 1215 Geneva, Switzerland – sequence: 7 givenname: Peter R orcidid: 0000-0002-0889-0859 surname: Boag fullname: Boag, Peter R organization: Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia – sequence: 8 givenname: Nghi surname: Nguyen fullname: Nguyen, Nghi organization: Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia – sequence: 9 givenname: Brad E orcidid: 0000-0001-9117-1048 surname: Sleebs fullname: Sleebs, Brad E organization: Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia – sequence: 10 givenname: Robin B orcidid: 0000-0002-4423-1690 surname: Gasser fullname: Gasser, Robin B organization: Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35215369$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_molecules28114365 crossref_primary_10_3389_fitd_2022_1017900 crossref_primary_10_3390_molecules29061241 crossref_primary_10_3390_ijms232415739 crossref_primary_10_3389_fphar_2022_1014804 crossref_primary_10_1371_journal_pntd_0011806 crossref_primary_10_1016_j_bmc_2023_117540 crossref_primary_10_1186_s13071_024_06183_y crossref_primary_10_3390_ph16091257 crossref_primary_10_1007_s00284_023_03601_9 crossref_primary_10_1016_j_ijpddr_2024_100522 |
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| Copyright | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 by the authors. 2022 |
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| Keywords | Caenorhabditis elegans Haemonchus contortus Pandemic Response Box parasitic nematode anthelmintics phenotypic screening small molecules |
| Language | English |
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