The Effect of the Extra Virgin Olive Oil Minor Phenolic Compound 3',4'-Dihydroxyphenylglycol in Experimental Diabetic Kidney Disease

• Published in: Nutrients Vol. 15; no. 2; p. 377
• Main Authors: Rodriguez-Pérez, María Dolores, Santiago-Corral, Laura, Ortega-Hombrados, Laura, Verdugo, Cristina, Arrebola, María Monsalud, Martín-Aurioles, Esther, Fernández-Prior, María África, Bermúdez-Oria, Alejandra, De La Cruz, José Pedro, González-Correa, José Antonio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11-01-2023; MDPI
• Subjects: 3′,4′-dihydroxyphenylglycol; Animals; Antioxidants; Biomarkers; Blood vessels; Coefficients; Creatinine; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Experimental - metabolism; Diabetic Nephropathies - drug therapy; Diabetic nephropathy; Enzymes; Excretion; Glucose; Immunoassay; Kidney diseases; Laboratory animals; nephropathy; Olive oil; Olive Oil - pharmacology; Oxidative Stress; Phenolic compounds; Phenols; Phenols - pharmacology; Polyphenols; Prostacyclin; Prostaglandins I - metabolism; Prostaglandins I - pharmacology; Proteins; Rats; Sustainable development; Urine; United States > US; Madrid Spain; Germany; Spain; nephropathy; diabetes mellitus; 3′,4′-dihydroxyphenylglycol; oxidative stress
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15020377

The aim of this study was to analyze the possible nephroprotective effect of 3',4'-dihydroxyphenylglycol (DHPG), a polyphenolic compound of extra virgin olive oil (EVOO), on renal lesions in an experimental model of type 1 diabetes. Rats were distributed as follows: healthy normoglycemic rats (NDR), diabetic rats treated with saline (DR), and DR treated with 0.5 mg/kg/day or 1 mg/kg/day of DHPG. DR showed a significantly higher serum and renal oxidative and nitrosative stress profile than NDR, as well as reduced prostacyclin production and renal damage (defined as urinary protein excretion, reduced creatinine clearance, increased glomerular volume, and increased glomerulosclerosis index). DHPG reduced the oxidative and nitrosative stress and increased prostacyclin production (a 59.2% reduction in DR and 34.7-7.8% reduction in DHPG-treated rats), as well as 38-56% reduction in urinary protein excretion and 22-46% reduction in glomerular morphological parameters (after the treatment with 0.5 or 1 mg/kg/day, respectively). Conclusions: DHPG administration to type 1-like diabetic rats exerts a nephroprotective effect probably due to the sum of its antioxidant (Pearson's coefficient 0.68-0.74), antinitrosative (Pearson's coefficient 0.83), and prostacyclin production regulator (Pearson's coefficient 0.75) effects.