Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity

• Published in: Marine drugs Vol. 20; no. 2; p. 103
• Main Authors: Oliveira, Verônica da Silva, Cruz, Meriângela Miranda da, Bezerra, Gabriela Suassuna, Silva, Natan Emanuell Sobral E, Nogueira, Fernando Henrique Andrade, Chaves, Guilherme Maranhão, Sobrinho, José Lamartine Soares, Mendonça-Junior, Francisco Jaime Bezerra, Damasceno, Bolívar Ponciano Goulart de Lima, Converti, Attilio, Lima, Ádley Antonini Neves de
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26-01-2022; MDPI
• Subjects: 2-aminothiophene derivative; Administration, Topical; Analytical methods; Antifungal activity; Antifungal Agents - administration & dosage; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Bioactive compounds; Biopolymers; Calorimetry; Candida; Candida - drug effects; Chitosan; Chitosan - chemistry; Differential scanning calorimetry; Drug Carriers - chemistry; Drug delivery systems; Drugs; Fourier transforms; Fungal infections; Fungicides; Halos; Infrared analysis; Infrared spectroscopy; Micrography; Microscopy; Pharmaceuticals; Photomicrographs; Physicochemical analysis; Polymers; Spectrum analysis; Thermal analysis; Thermogravimetric analysis; Thiophenes - chemistry; X-ray diffraction; chitosan; films; 2-aminothiophene derivative; antifungal activity
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md20020103

In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[
]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of
(
,
, and
). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against
species showing potential for application as a new antifungal drug.