Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study

• Published in: Nutrients Vol. 11; no. 7; p. 1477
• Main Authors: Angarita Dávila, Lisse, Bermúdez, Valmore, Aparicio, Daniel, Céspedes, Virginia, Escobar, Ma Cristina, Durán-Agüero, Samuel, Cisternas, Silvana, de Assis Costa, Jorge, Rojas-Gómez, Diana, Reyna, Nadia, López-Miranda, Jose
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28-06-2019; MDPI
• Subjects: Administration, Oral; Appetite; Appetite Regulation; Biomarkers - blood; Blood glucose; Blood Glucose - metabolism; Carbohydrate metabolism; Carbohydrates; Colon; Cross-Over Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - psychology; Dietary Supplements; Disaccharides - administration & dosage; Disaccharides - adverse effects; Double-Blind Method; Energy intake; Female; Food; Fructose - administration & dosage; Fructose - adverse effects; Gastric emptying; Gastric Inhibitory Polypeptide - blood; Glucagon-Like Peptide 1 - blood; Glucose; glycaemic index; Glycemic Index; Health care; Humans; incretins; Insulin; Insulin - blood; Insulin resistance; Intestinal microflora; Intestine; Isomaltose - administration & dosage; Isomaltose - adverse effects; isomaltulose; Male; Metabolism; Microbiomes; Microbiota; Middle Aged; Nutrients; Nutrition research; nutritional supplement; Obesity; Peptide Hormones - blood; Peptides; Secretion; Secretions; Small intestine; subjective appetite; sucromalt; Sucrose; Time Factors; Treatment Outcome; Brazil; Chile; Spain; subjective appetite; incretins; isomaltulose; nutritional supplement; sucromalt; glycaemic index
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11071477

Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (
< 0.001). The insulin area under the curve (AUC
) (
< 0.02) and GIP AUC (
< 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (
< 0.05). Subjective appetite AUC was greater after ET than ONS-D (
< 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors.