Fatigue sensation following peripheral viral infection is triggered by neuroinflammation: who will answer these questions?

• Published in: Neural regeneration research Vol. 10; no. 2; pp. 203 - 204
• Main Authors: Yamato, Masanori, Kataoka, Yosky
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01-02-2015; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Abnormalities; Animals; Blood-brain barrier; Causes of; Central nervous system; Chronic fatigue syndrome; Clinical trials; Complications and side effects; Cytokines; Fatigue; Fever; Infections; Nervous system; Neurological disorders; Tumor necrosis factor-TNF; Viral infections; Virus diseases
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.152369

Other studies have indicated that neuroinflammation is an important precipitating event in chronic neurological disorders including Alzheimer′s disease, Parkinson′s disease, and depression (Song and Wang, 2011; Fan et al., 2014). [...]an understanding of the regulatory mechanisms of neuroinflammation and the prevention of entering the chronic state is important. [...]the impairment of IL-1ra production in the brain could induce chronic neuroinflammation, and the balance of IL-1β and IL-1ra production in the brain is possibly involved in the pathogenesis of neurological disorders. In the past decade, minocycline has been shown to exert biological effects other than its antimicrobial action in experiments with cells or animals: suppression of the blood-brain barrier breakdown via suppression of matrix metalloproteinase (MMP)-9 production, alleviation of white matter injury in the neonatal rat brain via inhibition of IL-1β and TNF-α expression, neuroprotection from ischemic injury or contusion injury, attenuation of microglial activation, suppression of NOx production in cultured microglia under hypoxia, and alleviation of lipopolysaccharide-induced depressive-like behavior (Garrido-Mesa et al., 2013).