NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma

Invasive mucinous lung adenocarcinoma (IMA) is a rare subtype of lung adenocarcinoma with no effective treatment option in advanced disease. KRAS mutations occur in 28–87% of the cases. NRG1 fusions were recently discovered in KRAS‐negative IMA cases and otherwise negative for known driver oncogenes...

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Bibliographic Details
Published in:	Cancer medicine (Malden, MA) Vol. 5; no. 12; pp. 3579 - 3585
Main Authors:	Duruisseaux, Michaël, McLeer‐Florin, Anne, Antoine, Martine, Alavizadeh, Sanaz, Poulot, Virginie, Lacave, Roger, Rabbe, Nathalie, Cadranel, Jacques, Wislez, Marie
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-12-2016 Wiley John Wiley and Sons Inc
Subjects:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - pathology Aged Aged, 80 and over Biomarkers, Tumor Cancer Cancer Biology Cancer therapies Cloning Cohort Studies Deoxyribonucleic acid DNA Epidermal growth factor receptors ErbB-2 protein Ethnicity Female FISH Human health and pathology Humans Immunohistochemistry In Situ Hybridization, Fluorescence invasive mucinous adenocarcinoma Invasiveness Life Sciences lung adenocarcinoma Lung cancer Lung diseases Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Minority & ethnic groups molecular oncology Mutation Neoplasm Invasiveness Neuregulin-1 - genetics Neuregulin-1 - metabolism NRG1 Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pulmonology and respiratory tract Short Report Studies Therapeutic applications Tumors France Germany molecular oncology FISH invasive mucinous adenocarcinoma NRG1 lung adenocarcinoma
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