Preparation of a Functional GABARAP-Lipid Conjugate in Nanodiscs and its Investigation by Solution NMR Spectroscopy

The state you're in: GABARAP, a protein relevant for autophagic processes, has been enzymatically coupled to phosphatidylethanolamine in a ubiquitin‐like modification cascade. The lipidation state of GABARAP defines its subcellular localization pattern and is crucial to its functional integrity...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 11; no. 14; pp. 1967 - 1970
Main Authors:	Ma, Peixiang, Mohrlüder, Jeannine, Schwarten, Melanie, Stoldt, Matthias, Singh, Sameer K, Hartmann, Rudolf, Pacheco, Victor, Willbold, Dieter
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 24-09-2010 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects:	Adaptor Proteins, Signal Transducing - chemistry Humans membrane proteins Microtubule-Associated Proteins - chemistry Models, Molecular NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular Phosphatidylethanolamines - chemistry protein structures protein-protein interactions proteolipids
Online Access:	Get full text
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Summary:	The state you're in: GABARAP, a protein relevant for autophagic processes, has been enzymatically coupled to phosphatidylethanolamine in a ubiquitin‐like modification cascade. The lipidation state of GABARAP defines its subcellular localization pattern and is crucial to its functional integrity.
Bibliography:	http://dx.doi.org/10.1002/cbic.201000354 ArticleID:CBIC201000354 ark:/67375/WNG-TV2FGM2G-1 International Helmholtz Research School BioSoft istex:36DEFE64D0440FF7363A5BD7584E48C874C1D064 Deutsche Forschungsgemeinschaft - No. Wi1472/5 DAAD ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201000354