Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans

Resistance of nematodes to anthelmintics such as avermectins has emerged as a major global health and agricultural problem, but genes conferring natural resistance to avermectins are unknown. We show that a naturally occurring four-amino-acid deletion in the ligand-binding domain of GLC-1, the alpha...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 335; no. 6068; pp. 574 - 578
Main Authors:	Ghosh, Rajarshi, Andersen, Erik C., Shapiro, Joshua A., Gerke, Justin P., Kruglyak, Leonid
Format:	Journal Article
Language:	English
Published:	Washington, DC American Association for the Advancement of Science 03-02-2012 The American Association for the Advancement of Science
Subjects:	Alleles Amino Acid Sequence Amino acids Animal tales Animals Animals, Genetically Modified Antinematodal Agents - pharmacology Bacteria Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - chemistry Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Chemical control Chloride channels Chloride Channels - chemistry Chloride Channels - genetics Chloride Channels - metabolism Control Crosses, Genetic Drug resistance Drug Resistance - genetics Fundamental and applied biological sciences. Psychology Genes, Helminth Genetic loci Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Haplotypes Invertebrata Invertebrates Ivermectin - analogs & derivatives Ivermectin - pharmacology Ligands Molecular Sequence Data Mutation Nemathelminthia. Plathelmintha Nematodes Parasitic diseases Phenotypic traits Physiology. Development Phytopathology. Animal pests. Plant and forest protection Polymorphism, Single Nucleotide Population genetics, reproduction patterns Protein Structure, Tertiary Protozoa. Invertebrates Quantitative Trait Loci Selection, Genetic Soil bacteria Soil microorganisms Streptomyces - physiology Toxins Worms Nematicide Genetic variability Pesticides Parasite Ionic channel Caenorhabditis elegans Pest Phytophagous Sensitivity resistance Chlorides Helmintha Nemathelminthia Pesticide resistance Invertebrata Nematoda
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