Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
•In the study, we compared clinical characteristics of COVID-19 cases between cluster-onset families (COFs) and solitary-onset families (SOFs).•Patients with exposure to respiratory droplets and close contact, advanced age, and comorbidities were more likely to develop COVID-19 in COFs.•Advanced age...
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| Published in: | Virus research Vol. 286; p. 198043 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
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01-09-2020
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| Abstract | •In the study, we compared clinical characteristics of COVID-19 cases between cluster-onset families (COFs) and solitary-onset families (SOFs).•Patients with exposure to respiratory droplets and close contact, advanced age, and comorbidities were more likely to develop COVID-19 in COFs.•Advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in COFs.
An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs. |
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| AbstractList | An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs. • In the study, we compared clinical characteristics of COVID-19 cases between cluster-onset families (COFs) and solitary-onset families (SOFs). • Patients with exposure to respiratory droplets and close contact, advanced age, and comorbidities were more likely to develop COVID-19 in COFs. • Advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in COFs. An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs. •In the study, we compared clinical characteristics of COVID-19 cases between cluster-onset families (COFs) and solitary-onset families (SOFs).•Patients with exposure to respiratory droplets and close contact, advanced age, and comorbidities were more likely to develop COVID-19 in COFs.•Advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in COFs. An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs. |
| ArticleNumber | 198043 |
| Author | Zeng, Dongyu Li, Minran Li, Jinzhong Wang, Zhigang Li, Taoyuan Chen, Renzhou Gong, Xiaobing |
| Author_xml | – sequence: 1 givenname: Jinzhong surname: Li fullname: Li, Jinzhong organization: Departments of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China – sequence: 2 givenname: Xiaobing surname: Gong fullname: Gong, Xiaobing organization: Departments of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China – sequence: 3 givenname: Zhigang surname: Wang fullname: Wang, Zhigang organization: Departments of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China – sequence: 4 givenname: Renzhou surname: Chen fullname: Chen, Renzhou organization: Department of General Surgery, Hankou Hospital of Wuhan City, Wuhan 430312, Hubei Province, China – sequence: 5 givenname: Taoyuan surname: Li fullname: Li, Taoyuan organization: Departments of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China – sequence: 6 givenname: Dongyu surname: Zeng fullname: Zeng, Dongyu organization: Departments of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China – sequence: 7 givenname: Minran surname: Li fullname: Li, Minran email: muziran@126.com organization: Departments of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32502551$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1186/s13054-014-0731-6 10.1007/s15010-016-0972-1 10.1001/jama.2020.0757 10.1016/S0140-6736(20)30154-9 10.1056/NEJMoa2001316 10.1056/NEJMoa2001191 10.1111/hdi.12549 10.2147/TCRM.S206930 10.1016/S0140-6736(20)30183-5 10.1038/s41586-020-2008-3 |
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| Snippet | •In the study, we compared clinical characteristics of COVID-19 cases between cluster-onset families (COFs) and solitary-onset families (SOFs).•Patients with... An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic"... • In the study, we compared clinical characteristics of COVID-19 cases between cluster-onset families (COFs) and solitary-onset families (SOFs). • Patients... |
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| SubjectTerms | 2019 Coronavirus disease Adult Age Factors Aged Aged, 80 and over Betacoronavirus - pathogenicity Betacoronavirus - physiology China Cluster Analysis Cluster-onset families Comorbidity Coronary Disease - diagnosis Coronary Disease - mortality Coronary Disease - physiopathology Coronavirus Infections - diagnosis Coronavirus Infections - mortality Coronavirus Infections - physiopathology Coronavirus Infections - transmission COVID-19 Diabetes Mellitus - diagnosis Diabetes Mellitus - mortality Diabetes Mellitus - physiopathology Female Hospitalization Humans Hypertension - diagnosis Hypertension - mortality Hypertension - physiopathology Leukocyte Count Lymphocytes - pathology Lymphocytes - virology Male Middle Aged Neutrophils - pathology Neutrophils - virology Pandemics Pneumonia, Viral - diagnosis Pneumonia, Viral - mortality Pneumonia, Viral - physiopathology Pneumonia, Viral - transmission Retrospective Studies Risk Factors SARS-Coronavirus-2 SARS-CoV-2 Severity of Illness Index Solitary-onset families Survival Analysis |
| Title | Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China |
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