Abyssinone V-4’ Methyl Ether Isolated from Erythrina droogmansiana (Leguminosae) Inhibits Cell Growth and Mammary Glands Hyperplasia Induced in Swiss Mice by the 7,12-Dimethylbenz(a)anthracene

• Published in: Evidence-based complementary and alternative medicine Vol. 2018; no. 2018; pp. 1 - 10
• Main Authors: Njamen, Dieudonné, Njuh, Amstrong Nang, Gbaweng Yaya, Abel Joël, Gueyo, Telesphore Nanbo, Tchoupang, Edwige Nana, Zingue, Stephane, Tueche, Alain Brice, Ntsa, Dieudonnée Mireille
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2018; Hindawi; Hindawi Limited
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; Alveoli; Animal tissues; Anthracene; Apoptosis; Brain tumors; Breast cancer; Cancer; Cancer therapies; Cell cycle; Cell growth; Cell lines; Cervical cancer; Chromatography; Cytotoxicity; Flavonoids; Hyperplasia; Incidence; Mammary gland; Medical research; Medicinal plants; Mice; Molecular weight; Natural products; Tumor cell lines; Tumors; Womens health; Cameroon; Germany
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2018/7959068

There is a long standing interest in the identification of medicinal plants and derived natural products for developing cancer therapeutics. The present study was designed to evaluate the in vitro and in vivo antiproliferative effects of Abyssinone V-4’ methyl ether (AVME) on breast tissue of mice. The cytotoxicity of AVME was evaluated using MTT assay in four cancer cell lines (DU145, PC3, HepG2, and MCF-7). Further, a protective effect of AVME was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast tumor in Swiss mice. Incidence, burden, volume, and histological analysis of mammary tumors were measured. As a result, AVME inhibits DU145, PC3, HepG2, and MCF-7 cells growth. In vivo, no tumor was detected in mice from the normal group as compared to those of DMBA group. Moreover, AVME inhibits the DMBA-induced mammary glands hyperplasia in mice at the dose of 10 mg/kg, evidenced by a decrease of tumor incidence, tumor weight, and volume as well as a protective effect against the lobular alveolar hyperplasia. Taken all together, these results suggest that Abyssinone V-4’ methyl ether is endowed with antitumor properties and could be a source of traditional medicine which deserves to be more elucidated and explored in the foreseeable future.