Use of a new ziprasidone-selective electrode in mixed solvents and its application in the analysis of pharmaceuticals and biological fluids

• Published in: Sensors (Basel, Switzerland) Vol. 11; no. 9; pp. 8813 - 8825
• Main Authors: García, M Soledad, Ortuño, Joaquín A, Cuartero, María, Abuherba, Mustafa Salem
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-09-2011; Molecular Diversity Preservation International (MDPI)
• Subjects: Antipsychotics; Body Fluids - chemistry; Calibration; Electrodes; Humans; ion-selective electrode; Membranes, Artificial; mixed solvents; Pharmaceutical Preparations - analysis; Pharmaceuticals; Piperazines - chemistry; Psychotropic drugs; Sensors; serum; Solvents; Solvents - chemistry; Thiazoles - chemistry; urine; ziprasidone; United States > US; Germany; ion-selective electrode; ziprasidone; mixed solvents; pharmaceuticals; serum; urine
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s110908813

The construction and characterization of a new ion-selective electrode for the determination of the antipsychotic ziprasidone in mixed solvents is presented. The electrode contains a plasticized polymeric membrane based on a ziprasidone-tetraphenylborate ion-exchanger. The influence of membrane composition on the electrode response towards ziprasidone in hydroalcoholic solutions was studied. The electrode displayed a stable response in a 2:3 (v/v) methanol/water medium from a ziprasidone concentration of 3 × 10(-6) M with a fast response time of less than 20 s. The electrode also showed good selectivity towards ziprasidone over common inorganic and organic compounds and several species with pharmacological activity. The electrode was successfully applied to the determination of ziprasidone in pharmaceuticals and human urine and serum.