Detection of B-RAF and N-RAS mutations in human melanoma

It is now known that activating point mutations in components of the mitogen-activated protein kinase pathway commonly occur in melanoma. We previously described a method to detect point mutations in heterogenous tissues containing both wild-type and mutant B-RAF and N-RAS genes by using site-direct...

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Bibliographic Details
Published in:	Journal of the American College of Surgeons Vol. 200; no. 3; pp. 362 - 370
Main Authors:	Goydos, James S., Mann, Barbara, Kim, Hyunjin J., Gabriel, Emmanuel M., Alsina, Janivette, Germino, F. Joseph, Shih, Weichung, Gorski, David H.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-03-2005 Elsevier Science
Subjects:	Biological and medical sciences Biomarkers, Tumor - genetics Biopsy, Fine-Needle Blotting, Southern Cell Line, Tumor Dermatology DNA, Complementary - genetics Electrophoresis, Agar Gel General aspects Genes, ras - genetics Humans Medical sciences Melanoma - genetics Melanoma - pathology Mitogen-Activated Protein Kinases - genetics Paraffin Embedding Point Mutation - genetics Polymerase Chain Reaction Proto-Oncogene Proteins B-raf - genetics RNA, Messenger - genetics RNA, Neoplasm - genetics RNA, Neoplasm - isolation & purification Sensitivity and Specificity Skin Neoplasms - genetics Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions MAPK WT PCR Human Medicine BRAF Gene n ras Gene Surgery C-Onc gene Malignant melanoma Malignant tumor Diagnosis Detection Ras gene Protooncogene
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