Effects of Glycolipid Rhodococcus Biosurfactant on Innate and Adaptive Immunity Parameters In Vivo

• Published in: Bulletin of experimental biology and medicine Vol. 165; no. 3; pp. 368 - 372
• Main Authors: Gein, S. V., Kochina, O. A., Kuyukina, M. S., Ivshina, I. B.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2018; Springer; Springer Nature B.V
• Subjects: Adaptive immunity; Analysis; Antibodies; Antiviral agents; Biomedical and Life Sciences; Biomedicine; Biosurfactants; Cell Biology; Cytokines; Glycolipids; Immune response; Immunity (Disease); Immunology and Microbiology; Immunostimulation; Inflammation; Internal Medicine; Laboratory Medicine; Macrophages; Membrane lipids; Pathology; Peritoneum; Surfactants; antibody production; macrophages; cytokines; biosurfactant
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-018-4172-0

The glycolipid biosurfactant complex from actinobacterium
Rhodococcus ruber
IEGM 231 inhibits the innate and adaptive immunity parameters after intraperitoneal and intramuscular injection. Marked suppression of antibody production, bactericidal potential, and production of proinflammatory cytokines by peritoneal macrophages, detected
in vivo
, do not agree with the previously detected immunostimulatory activity of biosurfactants towards the immunocompetent cell cultures; this fact indicates an important role of the cell environment in the formation of immune response under the effect of bacterial glycolipids.