A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain
Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the targeting of acidified endosomes to precisely inh...
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| Published in: | Nature nanotechnology Vol. 14; no. 12; pp. 1150 - 1159 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
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Nature Publishing Group UK
01-12-2019
Nature Publishing Group |
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| Abstract | Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the targeting of acidified endosomes to precisely inhibit endosomal signalling events leading to chronic pain. In chronic pain, the substance P (SP) neurokinin 1 receptor (NK
1
R) redistributes from the plasma membrane to acidified endosomes, where it signals to maintain pain. Therefore, the NK
1
R in endosomes provides an important target for pain relief. The pH-responsive nanoparticles enter cells by clathrin- and dynamin-dependent endocytosis and accumulate in NK
1
R-containing endosomes. Following intrathecal injection into rodents, the nanoparticles, containing the FDA-approved NK
1
R antagonist aprepitant, inhibit SP-induced activation of spinal neurons and thus prevent pain transmission. Treatment with the nanoparticles leads to complete and persistent relief from nociceptive, inflammatory and neuropathic nociception and offers a much-needed non-opioid treatment option for chronic pain.
A pH-responsive, soft polymeric nanoparticle targets the neurokinin 1 receptor in acidified endosomes to inhibit signalling events leading to chronic pain. |
|---|---|
| AbstractList | Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the targeting of acidified endosomes to precisely inhibit endosomal signalling events leading to chronic pain. In chronic pain, the substance P (SP) neurokinin 1 receptor (NK1R) redistributes from the plasma membrane to acidified endosomes, where it signals to maintain pain. Therefore, the NK1R in endosomes provides an important target for pain relief. The pH-responsive nanoparticles enter cells by clathrin- and dynamin-dependent endocytosis and accumulate in NK1R-containing endosomes. Following intrathecal injection into rodents, the nanoparticles, containing the FDA-approved NK1R antagonist aprepitant, inhibit SP-induced activation of spinal neurons and thus prevent pain transmission. Treatment with the nanoparticles leads to complete and persistent relief from nociceptive, inflammatory and neuropathic nociception and offers a much-needed non-opioid treatment option for chronic pain. Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the targeting of acidified endosomes to precisely inhibit endosomal signalling events leading to chronic pain. In chronic pain, the substance P (SP) neurokinin 1 receptor (NK 1 R) redistributes from the plasma membrane to acidified endosomes, where it signals to maintain pain. Therefore, the NK 1 R in endosomes provides an important target for pain relief. The pH-responsive nanoparticles enter cells by clathrin- and dynamin-dependent endocytosis and accumulate in NK 1 R-containing endosomes. Following intrathecal injection into rodents, the nanoparticles, containing the FDA-approved NK 1 R antagonist aprepitant, inhibit SP-induced activation of spinal neurons and thus prevent pain transmission. Treatment with the nanoparticles leads to complete and persistent relief from nociceptive, inflammatory and neuropathic nociception and offers a much-needed non-opioid treatment option for chronic pain. A pH-responsive, soft polymeric nanoparticle targets the neurokinin 1 receptor in acidified endosomes to inhibit signalling events leading to chronic pain. Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the targeting of acidified endosomes to precisely inhibit endosomal signalling events leading to chronic pain. In chronic pain, the substance P (SP) neurokinin 1 receptor (NK R) redistributes from the plasma membrane to acidified endosomes, where it signals to maintain pain. Therefore, the NK R in endosomes provides an important target for pain relief. The pH-responsive nanoparticles enter cells by clathrin- and dynamin-dependent endocytosis and accumulate in NK R-containing endosomes. Following intrathecal injection into rodents, the nanoparticles, containing the FDA-approved NK R antagonist aprepitant, inhibit SP-induced activation of spinal neurons and thus prevent pain transmission. Treatment with the nanoparticles leads to complete and persistent relief from nociceptive, inflammatory and neuropathic nociception and offers a much-needed non-opioid treatment option for chronic pain. Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the targeting of acidified endosomes to precisely inhibit endosomal signalling events leading to chronic pain. In chronic pain, the substance P (SP) neurokinin 1 receptor (NK 1 R) redistributes from the plasma membrane to acidified endosomes, where it signals to maintain pain. Therefore, the NK 1 R in endosomes provides an important target for pain relief. The pH-responsive nanoparticles enter cells by clathrin- and dynamin-dependent endocytosis and accumulate in NK 1 R-containing endosomes. Following intrathecal injection into rodents, the nanoparticles, containing the FDA-approved NK 1 R antagonist aprepitant, inhibit SP-induced activation of spinal neurons and thus prevent pain transmission. Treatment with the nanoparticles leads to complete and persistent relief from nociceptive, inflammatory and neuropathic nociception and offers a much-needed nonopioid treatment option for chronic pain. |
| Author | Pelissier, Teresa Stewart, Gregory D. Veldhuis, Nicholas A. Khor, Song Y. Quinn, John F. Davis, Thomas P. Whittaker, Michael R. Shenoy, Priyank Lieu, TinaMarie Ramírez-García, Paulina D. Layani, Louis M. Scheff, Nicole N. Lumb, Chris Retamal, Jeffri S. Truong, Nghia Imlach, Wendy Latorre, Rocco Sykes, Matthew Nowell, Cameron J. Poole, Daniel P. Mai, Quynh N. Jensen, Dane D. Constandil, Luis Schmidt, Brian L. Bunnett, Nigel W. |
| AuthorAffiliation | 3 Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia 1 Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia 5 Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York, New York, NY, USA 8 Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia 2 Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia 4 Laboratory of Neurobiology, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), University of Santiago de Chile, Santiago, Chile 7 Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia 6 Bluestone Centre for Clinical Research, New York University College of Dentistry, New York, NY, USA |
| AuthorAffiliation_xml | – name: 3 Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia – name: 7 Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia – name: 8 Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia – name: 1 Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia – name: 4 Laboratory of Neurobiology, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), University of Santiago de Chile, Santiago, Chile – name: 2 Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia – name: 5 Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York, New York, NY, USA – name: 6 Bluestone Centre for Clinical Research, New York University College of Dentistry, New York, NY, USA |
| Author_xml | – sequence: 1 givenname: Paulina D. orcidid: 0000-0003-0971-3501 surname: Ramírez-García fullname: Ramírez-García, Paulina D. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 2 givenname: Jeffri S. surname: Retamal fullname: Retamal, Jeffri S. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 3 givenname: Priyank surname: Shenoy fullname: Shenoy, Priyank organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 4 givenname: Wendy orcidid: 0000-0002-7521-9969 surname: Imlach fullname: Imlach, Wendy organization: Monash Biomedicine Discovery Institute, Monash University – sequence: 5 givenname: Matthew surname: Sykes fullname: Sykes, Matthew organization: Monash Biomedicine Discovery Institute, Monash University – sequence: 6 givenname: Nghia orcidid: 0000-0001-9900-2644 surname: Truong fullname: Truong, Nghia organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 7 givenname: Luis orcidid: 0000-0002-2504-0119 surname: Constandil fullname: Constandil, Luis organization: Laboratory of Neurobiology, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), University of Santiago de Chile – sequence: 8 givenname: Teresa surname: Pelissier fullname: Pelissier, Teresa organization: Laboratory of Neurobiology, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), University of Santiago de Chile – sequence: 9 givenname: Cameron J. surname: Nowell fullname: Nowell, Cameron J. organization: Monash Institute of Pharmaceutical Sciences, Monash University – sequence: 10 givenname: Song Y. surname: Khor fullname: Khor, Song Y. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 11 givenname: Louis M. surname: Layani fullname: Layani, Louis M. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 12 givenname: Chris surname: Lumb fullname: Lumb, Chris organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 13 givenname: Daniel P. orcidid: 0000-0002-6168-8422 surname: Poole fullname: Poole, Daniel P. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 14 givenname: TinaMarie surname: Lieu fullname: Lieu, TinaMarie organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 15 givenname: Gregory D. surname: Stewart fullname: Stewart, Gregory D. organization: Monash Institute of Pharmaceutical Sciences, Monash University – sequence: 16 givenname: Quynh N. surname: Mai fullname: Mai, Quynh N. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 17 givenname: Dane D. surname: Jensen fullname: Jensen, Dane D. organization: Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York – sequence: 18 givenname: Rocco surname: Latorre fullname: Latorre, Rocco organization: Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York – sequence: 19 givenname: Nicole N. surname: Scheff fullname: Scheff, Nicole N. organization: Bluestone Centre for Clinical Research, New York University College of Dentistry – sequence: 20 givenname: Brian L. surname: Schmidt fullname: Schmidt, Brian L. organization: Bluestone Centre for Clinical Research, New York University College of Dentistry – sequence: 21 givenname: John F. surname: Quinn fullname: Quinn, John F. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 22 givenname: Michael R. surname: Whittaker fullname: Whittaker, Michael R. organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 23 givenname: Nicholas A. surname: Veldhuis fullname: Veldhuis, Nicholas A. email: nicholas.veldhuis@monash.edu organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University – sequence: 24 givenname: Thomas P. orcidid: 0000-0003-2581-4986 surname: Davis fullname: Davis, Thomas P. email: thomas.p.davis@monash.edu organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Australian Institute for Bioengineering and Nanotechnology, University of Queensland – sequence: 25 givenname: Nigel W. orcidid: 0000-0003-3367-0644 surname: Bunnett fullname: Bunnett, Nigel W. email: nwb2@nyu.edu organization: Monash Institute of Pharmaceutical Sciences, Monash University, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York, Department of Pharmacology and Therapeutics, University of Melbourne |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31686009$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/288370a0 10.1038/nrd.2017.178 10.1016/j.tips.2018.08.003 10.1016/0306-4522(95)00343-H 10.1016/j.tips.2017.09.005 10.2147/IJN.S596 10.1002/1521-3773(20010504)40:9<1707::AID-ANIE17070>3.0.CO;2-F 10.1038/nprot.2014.046 10.1124/mol.115.099499 10.1038/natrevmats.2016.14 10.1089/neu.2010.1700 10.1126/scitranslmed.aal3447 10.1021/nn403325f 10.1038/nchembio.1611 10.1016/j.neuron.2018.04.021 10.1038/nprot.2014.106 10.1021/cr940351u 10.1016/j.pain.2014.07.024 10.1021/mp100253e 10.1073/pnas.0906541106 10.1016/0091-3057(88)90372-3 10.1021/nn900002m 10.1126/science.7539937 10.1016/0304-3959(83)90201-4 10.1073/pnas.1721891115 10.1073/pnas.1706656114 10.3389/fphar.2018.01143 10.1016/j.neuron.2015.11.001 10.1126/science.281.5383.1640 10.1152/physrev.00031.2013 10.1016/j.ceb.2013.10.003 10.1038/nmeth.2019 10.1016/j.addr.2006.09.020 10.1517/13543780903379530 10.1016/S0168-3659(99)00248-5 10.1002/anie.201100884 10.1038/nchembio.2389 10.1111/j.1365-2818.1993.tb03313.x 10.1016/S0304-3959(00)00276-1 10.1002/adma.201405084 10.1038/nmat3776 |
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| Copyright | The Author(s), under exclusive licence to Springer Nature Limited 2019 Copyright Nature Publishing Group Dec 2019 |
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| Issue | 12 |
| Language | English |
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| Notes | P.D.R.-G. prepared and characterized nanoparticles, examined nanoparticle uptake and disassembly, studied SP signalling in model cells and wrote the manuscript. J.S.R. studied the biodistribution and anti-nociceptive and in vivo electrophysiological actions of nanoparticles. P.S. studied the biodistribution and anti-nociceptive actions of nanoparticles. W.I. conceived and designed electrophysiological studies on spinal neurons. M.S. studied the excitation of spinal neurons, and N.T. prepared and characterized nanoparticles. L.C. conceived and designed neuropathic nociception and in vivo electrophysiological studies. T.P. conceived and designed neuropathic nociception. C.J.N. provided expertise in the analysis of confocal images and S.Y.K. obtained transmission electron microscopy images. L.M.L. characterized the critical micellar concentration and pH-disassembly of nanoparticles. C.L. studied SP signalling in model cells and D.P.P. studied nanoparticle uptake. T.M.L. studied anti-nociceptive actions of nanoparticles, G.D.S. prepared striatal neurons, and Q.N.M. prepared and characterized nanoparticles. D.D.J. examined NK1R endocytosis, nanoparticle uptake into spinal neurons, and SP signalling in model cells and striatal neurons. R.L. examined NK1R endocytosis and nanoparticle uptake into spinal neurons. N.S.N. studied NK1R endocytosis in rats. B.L.S. designed experiments to examine NK1R endocytosis in rats. J.F.Q. designed nanoparticles and wrote the manuscript. M.R.W. designed nanoparticles. N.A.V. conceived experiments, studied SP signalling in neurons, interpreted the results and wrote the manuscript. T.P.D. conceived the experiments and designed the nanoparticles. N.W.B. conceived and designed the experiments, interpreted the results and wrote the manuscript. Author contributions |
| ORCID | 0000-0002-2504-0119 0000-0001-9900-2644 0000-0003-3367-0644 0000-0003-0971-3501 0000-0002-7521-9969 0000-0002-6168-8422 0000-0003-2581-4986 |
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| PublicationCentury | 2000 |
| PublicationDate | 2019-12-01 |
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| PublicationTitle | Nature nanotechnology |
| PublicationTitleAbbrev | Nat. Nanotechnol |
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| PublicationYear | 2019 |
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| References | Uhrich, Cannizzaro, Langer, Shakesheff (CR3) 1999; 99 Thomsen, Jensen, Hicks, Bunnett (CR13) 2018; 39 Such, Yan, Johnston, Gunawan, Caruso (CR5) 2015; 27 Chan, Farokhzad, Gao (CR6) 2010; 7 Vilardaga, Jean-Alphonse, Gardella (CR16) 2014; 10 Maeda (CR4) 2000; 65 Stoeber (CR18) 2018; 98 Quartara, Altamura, Evangelista, Maggi (CR23) 2009; 18 De Jong, Borm (CR1) 2008; 3 Zhou (CR11) 2011; 50 Stein, Millan, Herz (CR29) 1988; 31 Steinhoff, Von Mentzer, Geppetti, Pothoulakis, Bunnett (CR24) 2014; 94 Zimmermann (CR37) 1983; 16 Farokhzad, Langer (CR2) 2009; 3 Bravo (CR31) 2014; 155 Schindelin (CR36) 2012; 9 Nelson (CR12) 2013; 7 Wilhelm (CR10) 2016; 1 Decosterd, Woolf (CR30) 2000; 87 Geppetti, Veldhuis, Lieu, Bunnett (CR33) 2015; 88 Halls, Canals (CR34) 2018; 39 Randall, Selitto (CR38) 1957; 111 Di Porzio, Daguet, Glowinski, Prochiantz (CR42) 1980; 288 Murphy, Padilla, Hasdemir, Cottrell, Bunnett (CR15) 2009; 106 Schmaljohann (CR9) 2006; 58 Irannejad (CR17) 2017; 13 Kramer (CR22) 1998; 281 Santos-Nogueira, Redondo Castro, Mancuso, Navarro (CR39) 2012; 29 Robertson, Deane, Robinson, McCluskey (CR27) 2014; 9 Mura, Nicolas, Couvreur (CR8) 2013; 12 Hauser, Attwood, Rask-Andersen, Schiöth, Gloriam (CR14) 2017; 16 Abbadie, Brown, Mantyh, Basbaum (CR32) 1996; 70 Lynn, Amiji, Langer (CR7) 2001; 40 Retamal (CR40) 2018; 9 Irannejad, von Zastrow (CR35) 2014; 27 Manders, Verbeek, Aten (CR25) 1993; 169 Robertson (CR26) 2014; 9 Imlach, Bhola, May, Christopoulos, Macdonald (CR41) 2015; 88 Jimenez-Vargas (CR20) 2018; 115 Yarwood (CR21) 2017; 114 Jensen (CR19) 2017; 9 Mantyh (CR28) 1995; 268 NN Jimenez-Vargas (568_CR20) 2018; 115 RE Yarwood (568_CR21) 2017; 114 H Maeda (568_CR4) 2000; 65 PW Mantyh (568_CR28) 1995; 268 S Wilhelm (568_CR10) 2016; 1 WH De Jong (568_CR1) 2008; 3 L Quartara (568_CR23) 2009; 18 S Mura (568_CR8) 2013; 12 M Zimmermann (568_CR37) 1983; 16 LO Randall (568_CR38) 1957; 111 MS Kramer (568_CR22) 1998; 281 MS Steinhoff (568_CR24) 2014; 94 CE Nelson (568_CR12) 2013; 7 M Stoeber (568_CR18) 2018; 98 MJ Robertson (568_CR27) 2014; 9 J Retamal (568_CR40) 2018; 9 E Santos-Nogueira (568_CR39) 2012; 29 D Bravo (568_CR31) 2014; 155 JE Murphy (568_CR15) 2009; 106 P Geppetti (568_CR33) 2015; 88 C Stein (568_CR29) 1988; 31 R Irannejad (568_CR35) 2014; 27 JM Chan (568_CR6) 2010; 7 WL Imlach (568_CR41) 2015; 88 I Decosterd (568_CR30) 2000; 87 GK Such (568_CR5) 2015; 27 OC Farokhzad (568_CR2) 2009; 3 DD Jensen (568_CR19) 2017; 9 KE Uhrich (568_CR3) 1999; 99 K Zhou (568_CR11) 2011; 50 ML Halls (568_CR34) 2018; 39 DM Lynn (568_CR7) 2001; 40 JP Vilardaga (568_CR16) 2014; 10 C Abbadie (568_CR32) 1996; 70 J Schindelin (568_CR36) 2012; 9 ARB Thomsen (568_CR13) 2018; 39 EMM Manders (568_CR25) 1993; 169 U Di Porzio (568_CR42) 1980; 288 MJ Robertson (568_CR26) 2014; 9 D Schmaljohann (568_CR9) 2006; 58 AS Hauser (568_CR14) 2017; 16 R Irannejad (568_CR17) 2017; 13 |
| References_xml | – volume: 9 start-page: eaal3447 year: 2017 ident: CR19 article-title: Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief publication-title: Sci. Transl. Med. contributor: fullname: Jensen – volume: 18 start-page: 1843 year: 2009 end-page: 1864 ident: CR23 article-title: Tachykinin receptor antagonists in clinical trials publication-title: Expert Opin. Investig. Drugs contributor: fullname: Maggi – volume: 9 start-page: 1143 year: 2018 ident: CR40 article-title: Burst-like subcutaneous electrical stimulation induces BDNF-mediated, cyclotraxin B-sensitive central sensitization in rat spinal cord publication-title: Front. Pharmacol. contributor: fullname: Retamal – volume: 3 start-page: 133 year: 2008 end-page: 149 ident: CR1 article-title: Drug delivery and nanoparticles: applications and hazards publication-title: Int. J. Nanomed. contributor: fullname: Borm – volume: 98 start-page: 963 year: 2018 end-page: 976 ident: CR18 article-title: A genetically encoded biosensor reveals location bias of opioid drug action publication-title: Neuron contributor: fullname: Stoeber – volume: 9 start-page: 1592 year: 2014 end-page: 1606 ident: CR26 article-title: Synthesis of the PitStop family of clathrin inhibitors publication-title: Nat. Protoc. contributor: fullname: Robertson – volume: 88 start-page: 635 year: 2015 end-page: 649 ident: CR33 article-title: G protein-coupled receptors: dynamic machines for signaling pain and itch publication-title: Neuron contributor: fullname: Bunnett – volume: 115 start-page: E7438 year: 2018 end-page: E7447 ident: CR20 article-title: Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Jimenez-Vargas – volume: 27 start-page: 2278 year: 2015 end-page: 2297 ident: CR5 article-title: Interfacing materials science and biology for drug carrier design publication-title: Adv. Mater. contributor: fullname: Caruso – volume: 7 start-page: 1913 year: 2010 end-page: 1920 ident: CR6 article-title: pH-responsive nanoparticles for drug delivery publication-title: Mol. Pharm. contributor: fullname: Gao – volume: 16 start-page: 829 year: 2017 end-page: 842 ident: CR14 article-title: Trends in GPCR drug discovery: new agents, targets and indications publication-title: Nat. Rev. Drug Discov. contributor: fullname: Gloriam – volume: 10 start-page: 700 year: 2014 end-page: 706 ident: CR16 article-title: Endosomal generation of cAMP in GPCR signaling publication-title: Nat. Chem. Biol. contributor: fullname: Gardella – volume: 169 start-page: 375 year: 1993 end-page: 382 ident: CR25 article-title: Measurement of co-localization of objects in dual-colour confocal images publication-title: J. Microsc. contributor: fullname: Aten – volume: 268 start-page: 1629 year: 1995 end-page: 1632 ident: CR28 article-title: Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation publication-title: Science contributor: fullname: Mantyh – volume: 39 start-page: 879 year: 2018 end-page: 891 ident: CR13 article-title: Therapeutic targeting of endosomal G protein-coupled receptors publication-title: Trends Pharmacol. Sci. contributor: fullname: Bunnett – volume: 106 start-page: 17615 year: 2009 end-page: 17622 ident: CR15 article-title: Endosomes: a legitimate platform for the signaling train publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Bunnett – volume: 70 start-page: 201 year: 1996 end-page: 209 ident: CR32 article-title: Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain publication-title: Neuroscience contributor: fullname: Basbaum – volume: 12 start-page: 991 year: 2013 end-page: 1003 ident: CR8 article-title: Stimuli-responsive nanocarriers for drug delivery publication-title: Nat. Mater. contributor: fullname: Couvreur – volume: 114 start-page: 12309 year: 2017 end-page: 12314 ident: CR21 article-title: Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Yarwood – volume: 29 start-page: 898 year: 2012 end-page: 904 ident: CR39 article-title: Randall–Selitto test: a new approach for the detection of neuropathic pain after spinal cord injury publication-title: J. Neurotrauma contributor: fullname: Navarro – volume: 3 start-page: 16 year: 2009 end-page: 20 ident: CR2 article-title: Impact of nanotechnology on drug delivery publication-title: ACS Nano contributor: fullname: Langer – volume: 16 start-page: 109 year: 1983 end-page: 110 ident: CR37 article-title: Ethical guidelines for investigations of experimental pain in conscious animals publication-title: Pain contributor: fullname: Zimmermann – volume: 1 start-page: 16014 year: 2016 ident: CR10 article-title: Analysis of nanoparticle delivery to tumours publication-title: Nat. Rev. Mater. contributor: fullname: Wilhelm – volume: 31 start-page: 445 year: 1988 end-page: 451 ident: CR29 article-title: Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds publication-title: Pharmacol. Biochem. Behav. contributor: fullname: Herz – volume: 99 start-page: 3181 year: 1999 end-page: 3198 ident: CR3 article-title: Polymeric systems for controlled drug release publication-title: Chem. Rev. contributor: fullname: Shakesheff – volume: 13 start-page: 799 year: 2017 end-page: 806 ident: CR17 article-title: Functional selectivity of GPCR-directed drug action through location bias publication-title: Nat. Chem. Biol. contributor: fullname: Irannejad – volume: 88 start-page: 460 year: 2015 end-page: 468 ident: CR41 article-title: A positive allosteric modulator of the adenosine α1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain model publication-title: Mol. Pharmacol. contributor: fullname: Macdonald – volume: 65 start-page: 271 year: 2000 end-page: 284 ident: CR4 article-title: Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review publication-title: J. Control Rel. contributor: fullname: Maeda – volume: 50 start-page: 6109 year: 2011 end-page: 6114 ident: CR11 article-title: Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells publication-title: Angew. Chem. Int. Ed. contributor: fullname: Zhou – volume: 9 start-page: 676 year: 2012 end-page: 682 ident: CR36 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods contributor: fullname: Schindelin – volume: 27 start-page: 109 year: 2014 end-page: 116 ident: CR35 article-title: GPCR signaling along the endocytic pathway publication-title: Curr. Opin. Cell Biol. contributor: fullname: von Zastrow – volume: 111 start-page: 409 year: 1957 end-page: 419 ident: CR38 article-title: A method for measurement of analgesic activity on inflamed tissue publication-title: Arch. Int. Pharmacodyn. Ther. contributor: fullname: Selitto – volume: 58 start-page: 1655 year: 2006 end-page: 1670 ident: CR9 article-title: Thermo- and pH-responsive polymers in drug delivery publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Schmaljohann – volume: 7 start-page: 8870 year: 2013 end-page: 8880 ident: CR12 article-title: Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time and bioactivity in vivo publication-title: ACS Nano contributor: fullname: Nelson – volume: 40 start-page: 1707 year: 2001 end-page: 1710 ident: CR7 article-title: pH-responsive polymer microspheres: rapid release of encapsulated material within the range of intracellular pH publication-title: Angew. Chem. Int. Ed. contributor: fullname: Langer – volume: 9 start-page: 851 year: 2014 end-page: 870 ident: CR27 article-title: Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase publication-title: Nat. Protoc. contributor: fullname: McCluskey – volume: 155 start-page: 2108 year: 2014 end-page: 2115 ident: CR31 article-title: Pannexin 1: a novel participant in neuropathic pain signaling in the rat spinal cord publication-title: Pain contributor: fullname: Bravo – volume: 39 start-page: 148 year: 2018 end-page: 157 ident: CR34 article-title: Genetically encoded FRET biosensors to illuminate compartmentalised GPCR signalling publication-title: Trends Pharmacol. Sci. contributor: fullname: Canals – volume: 94 start-page: 265 year: 2014 end-page: 301 ident: CR24 article-title: Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease publication-title: Physiol. Rev. contributor: fullname: Bunnett – volume: 281 start-page: 1640 year: 1998 end-page: 1645 ident: CR22 article-title: Distinct mechanism for antidepressant activity by blockade of central substance P receptors publication-title: Science contributor: fullname: Kramer – volume: 87 start-page: 149 year: 2000 end-page: 158 ident: CR30 article-title: Spared nerve injury: an animal model of persistent peripheral neuropathic pain publication-title: Pain contributor: fullname: Woolf – volume: 288 start-page: 370 year: 1980 end-page: 373 ident: CR42 article-title: Effect of striatal cells on in vitro maturation of mesencephalic dopaminergic neurones grown in serum-free conditions publication-title: Nature contributor: fullname: Prochiantz – volume: 288 start-page: 370 year: 1980 ident: 568_CR42 publication-title: Nature doi: 10.1038/288370a0 contributor: fullname: U Di Porzio – volume: 16 start-page: 829 year: 2017 ident: 568_CR14 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd.2017.178 contributor: fullname: AS Hauser – volume: 39 start-page: 879 year: 2018 ident: 568_CR13 publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2018.08.003 contributor: fullname: ARB Thomsen – volume: 70 start-page: 201 year: 1996 ident: 568_CR32 publication-title: Neuroscience doi: 10.1016/0306-4522(95)00343-H contributor: fullname: C Abbadie – volume: 39 start-page: 148 year: 2018 ident: 568_CR34 publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2017.09.005 contributor: fullname: ML Halls – volume: 3 start-page: 133 year: 2008 ident: 568_CR1 publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S596 contributor: fullname: WH De Jong – volume: 40 start-page: 1707 year: 2001 ident: 568_CR7 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/1521-3773(20010504)40:9<1707::AID-ANIE17070>3.0.CO;2-F contributor: fullname: DM Lynn – volume: 9 start-page: 851 year: 2014 ident: 568_CR27 publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.046 contributor: fullname: MJ Robertson – volume: 88 start-page: 460 year: 2015 ident: 568_CR41 publication-title: Mol. Pharmacol. doi: 10.1124/mol.115.099499 contributor: fullname: WL Imlach – volume: 1 start-page: 16014 year: 2016 ident: 568_CR10 publication-title: Nat. Rev. Mater. doi: 10.1038/natrevmats.2016.14 contributor: fullname: S Wilhelm – volume: 29 start-page: 898 year: 2012 ident: 568_CR39 publication-title: J. Neurotrauma doi: 10.1089/neu.2010.1700 contributor: fullname: E Santos-Nogueira – volume: 9 start-page: eaal3447 year: 2017 ident: 568_CR19 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aal3447 contributor: fullname: DD Jensen – volume: 7 start-page: 8870 year: 2013 ident: 568_CR12 publication-title: ACS Nano doi: 10.1021/nn403325f contributor: fullname: CE Nelson – volume: 10 start-page: 700 year: 2014 ident: 568_CR16 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.1611 contributor: fullname: JP Vilardaga – volume: 98 start-page: 963 year: 2018 ident: 568_CR18 publication-title: Neuron doi: 10.1016/j.neuron.2018.04.021 contributor: fullname: M Stoeber – volume: 9 start-page: 1592 year: 2014 ident: 568_CR26 publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.106 contributor: fullname: MJ Robertson – volume: 99 start-page: 3181 year: 1999 ident: 568_CR3 publication-title: Chem. Rev. doi: 10.1021/cr940351u contributor: fullname: KE Uhrich – volume: 155 start-page: 2108 year: 2014 ident: 568_CR31 publication-title: Pain doi: 10.1016/j.pain.2014.07.024 contributor: fullname: D Bravo – volume: 7 start-page: 1913 year: 2010 ident: 568_CR6 publication-title: Mol. Pharm. doi: 10.1021/mp100253e contributor: fullname: JM Chan – volume: 106 start-page: 17615 year: 2009 ident: 568_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0906541106 contributor: fullname: JE Murphy – volume: 31 start-page: 445 year: 1988 ident: 568_CR29 publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/0091-3057(88)90372-3 contributor: fullname: C Stein – volume: 3 start-page: 16 year: 2009 ident: 568_CR2 publication-title: ACS Nano doi: 10.1021/nn900002m contributor: fullname: OC Farokhzad – volume: 268 start-page: 1629 year: 1995 ident: 568_CR28 publication-title: Science doi: 10.1126/science.7539937 contributor: fullname: PW Mantyh – volume: 16 start-page: 109 year: 1983 ident: 568_CR37 publication-title: Pain doi: 10.1016/0304-3959(83)90201-4 contributor: fullname: M Zimmermann – volume: 115 start-page: E7438 year: 2018 ident: 568_CR20 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1721891115 contributor: fullname: NN Jimenez-Vargas – volume: 114 start-page: 12309 year: 2017 ident: 568_CR21 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1706656114 contributor: fullname: RE Yarwood – volume: 9 start-page: 1143 year: 2018 ident: 568_CR40 publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.01143 contributor: fullname: J Retamal – volume: 88 start-page: 635 year: 2015 ident: 568_CR33 publication-title: Neuron doi: 10.1016/j.neuron.2015.11.001 contributor: fullname: P Geppetti – volume: 111 start-page: 409 year: 1957 ident: 568_CR38 publication-title: Arch. Int. Pharmacodyn. Ther. contributor: fullname: LO Randall – volume: 281 start-page: 1640 year: 1998 ident: 568_CR22 publication-title: Science doi: 10.1126/science.281.5383.1640 contributor: fullname: MS Kramer – volume: 94 start-page: 265 year: 2014 ident: 568_CR24 publication-title: Physiol. Rev. doi: 10.1152/physrev.00031.2013 contributor: fullname: MS Steinhoff – volume: 27 start-page: 109 year: 2014 ident: 568_CR35 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2013.10.003 contributor: fullname: R Irannejad – volume: 9 start-page: 676 year: 2012 ident: 568_CR36 publication-title: Nat. Methods doi: 10.1038/nmeth.2019 contributor: fullname: J Schindelin – volume: 58 start-page: 1655 year: 2006 ident: 568_CR9 publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2006.09.020 contributor: fullname: D Schmaljohann – volume: 18 start-page: 1843 year: 2009 ident: 568_CR23 publication-title: Expert Opin. Investig. Drugs doi: 10.1517/13543780903379530 contributor: fullname: L Quartara – volume: 65 start-page: 271 year: 2000 ident: 568_CR4 publication-title: J. Control Rel. doi: 10.1016/S0168-3659(99)00248-5 contributor: fullname: H Maeda – volume: 50 start-page: 6109 year: 2011 ident: 568_CR11 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201100884 contributor: fullname: K Zhou – volume: 13 start-page: 799 year: 2017 ident: 568_CR17 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2389 contributor: fullname: R Irannejad – volume: 169 start-page: 375 year: 1993 ident: 568_CR25 publication-title: J. Microsc. doi: 10.1111/j.1365-2818.1993.tb03313.x contributor: fullname: EMM Manders – volume: 87 start-page: 149 year: 2000 ident: 568_CR30 publication-title: Pain doi: 10.1016/S0304-3959(00)00276-1 contributor: fullname: I Decosterd – volume: 27 start-page: 2278 year: 2015 ident: 568_CR5 publication-title: Adv. Mater. doi: 10.1002/adma.201405084 contributor: fullname: GK Such – volume: 12 start-page: 991 year: 2013 ident: 568_CR8 publication-title: Nat. Mater. doi: 10.1038/nmat3776 contributor: fullname: S Mura |
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| SubjectTerms | 631/61 631/61/350/354 Acidification Animals Aprepitant - administration & dosage Aprepitant - pharmacokinetics Aprepitant - therapeutic use Cell Line Chemistry and Materials Science Chronic pain Chronic Pain - drug therapy Chronic Pain - metabolism Clathrin Delayed-Action Preparations - metabolism Drug delivery Drug Delivery Systems Dynamin Endocytosis Endosomes Endosomes - metabolism HEK293 Cells Humans Hydrogen-Ion Concentration Inflammation Male Materials Science Mice, Inbred C57BL Nanoparticles Nanoparticles - metabolism Nanotechnology Nanotechnology and Microengineering Neurokinin Neurokinin NK1 receptors Neurokinin-1 Receptor Antagonists - administration & dosage Neurokinin-1 Receptor Antagonists - pharmacokinetics Neurokinin-1 Receptor Antagonists - therapeutic use Opioids Pain Pain perception pH effects Rats Receptors, Neurokinin-1 - metabolism Substance P |
| Title | A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain |
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