Effects on Alimentary High-Fat Diet on Thiol Disulfide Homeostasis in Rats

• Published in: Bulletin of experimental biology and medicine Vol. 155; no. 6; pp. 752 - 756
• Main Authors: Karaman, Yu. K., Novgorodtseva, T. P., Yan’kova, V. I.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-10-2013; Springer; Springer Nature B.V
• Subjects: Animals; Antioxidants; Biomedical and Life Sciences; Biomedicine; Cell Biology; Diet, High-Fat; Digestive System - metabolism; Glutathione Disulfide - blood; Homeostasis; Internal Medicine; Laboratory Medicine; Lipid Peroxidation; Liver - metabolism; Male; Oxidation-Reduction; Oxidative Stress; Pathology; Physiological aspects; Rats; Rats, Wistar; Resveratrol; Thiols; thiol disulfide homeostasis; high-fat diet; glutathione redox system
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-013-2244-8

The effects of high-fat diet on the thiol disulfide homeostasis of rats were evaluated by activities of glutathione redox system functioning in the blood and liver. A short-term (30 days) high-fat diet inhibited activities of glutathione-dependent enzymes. High-fat loading for 90 days promoted the development of a compensatory response of the glutathione redox system and restoration of the thiol disulfide homeostasis. The compensatory processes in the glutathione system failed on day 180 of alimentary loading because of redox imbalance in the thiol disulfide metabolism.