Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision

Purpose: The purpose of this study was to determine the objective response rate (ORR) following treatment of canine mast cell tumors (MCT) with toceranib phosphate (Palladia, SU11654), a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 15; no. 11; pp. 3856 - 3865
Main Authors:	London, Cheryl A, Malpas, Phyllis B, Wood-Follis, Stacey L, Boucher, Joseph F, Rusk, Anthony W, Rosenberg, Mona P, Henry, Carolyn J, Mitchener, Kathy L, Klein, Mary K, Hintermeister, John G, Bergman, Philip J, Couto, Guillermo C, Mauldin, Guy N, Michels, Gina M
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-06-2009
Subjects:	Animals Anorexia - chemically induced Antineoplastic agents Biological and medical sciences Diarrhea - chemically induced Disease Progression dog Dog Diseases - drug therapy Dog Diseases - metabolism Dog Diseases - pathology Dogs Female Indoles - administration & dosage Indoles - adverse effects Indoles - therapeutic use kinase inhibitor Male mast cell tumor Mast-Cell Sarcoma - drug therapy Mast-Cell Sarcoma - metabolism Mast-Cell Sarcoma - pathology Medical sciences Neoplasm Recurrence, Local Pharmacology. Drug treatments Pyrroles - administration & dosage Pyrroles - adverse effects Pyrroles - therapeutic use Random Allocation Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism SU11654 Treatment Outcome Vomiting - chemically induced Phosphates Fissipedia Carnivora Relapse Excision Oral administration trk receptor Vertebrata Randomization Mammalia Treatment Animal Surgery Placebo Double blind study Mast cell Dog Tumor cell
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