XFEL structures of the influenza M2 proton channel Room temperature water networks and insights into proton conduction

The M2 proton channel of influenza A is a drug target that is essential for the reproduction of the flu virus. It is also a model system for the study of selective, unidirectional proton transport across amembrane. Ordered water molecules arranged in “wires” inside the channel pore have been propose...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 51; pp. 13357 - 13362
Main Authors:	Thomaston, Jessica L., Woldeyes, Rahel A., Nakane (中根崇智), Takanori, Yamashita, Ayumi, Tanaka, Tomoyuki, Koiwai, Kotaro, Brewster, Aaron S., Barad, Benjamin A., Chen, Yujie, Lemmin, Thomas, Uervirojnangkoorn, Monarin, Arima, Toshi, Kobayashi, Jun, Masuda, Tetsuya, Suzuki, Mamoru, Sugahara, Michihiro, Sauter, Nicholas K., Tanaka, Rie, Nureki, Osamu, Tono, Kensuke, Joti, Yasumasa, Nango, Eriko, Iwata, So, Yumoto, Fumiaki, Fraser, James S., DeGrado, William F.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 19-12-2017 National Academy of Sciences, Washington, DC (United States)
Subjects:	60 APPLIED LIFE SCIENCES BASIC BIOLOGICAL SCIENCES Channel gating Chemical bonds Conduction Hydrogen bonding Hydrogen bonds Influenza Influenza A membrane protein Membranes Molecules pH effects Physical Sciences proton channel Proton conduction Protonation Protons Radiation Radiation damage Radiation effects Temperature Viruses Water chemistry XFEL influenza proton channel membrane protein XFEL
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