Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions

Rett syndrome (RTT) and Fragile X syndrome (FXS) are two monogenetic neurodevelopmental disorders with complex clinical presentations. RTT is caused by mutations in the Methyl-CpG binding protein 2 gene ( MECP2 ) altering the function of its protein product MeCP2. MeCP2 modulates gene expression by...

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Bibliographic Details
Published in:	Frontiers in cellular neuroscience Vol. 15; p. 764761
Main Authors:	Bach, Snow, Shovlin, Stephen, Moriarty, Michael, Bardoni, Barbara, Tropea, Daniela
Format:	Journal Article
Language:	English
Published:	Lausanne Frontiers Research Foundation 19-11-2021 Frontiers Media S.A
Subjects:	CpG islands Etiology FMR1 gene FMR1 protein FMRP Fragile X syndrome Gene expression Genes Intellectual disabilities Males MeCP2 MeCP2 protein Methyl-CpG binding protein MicroRNAs Mutation Neurodevelopmental disorders Neuroscience Neurosciences Proteins Rett syndrome RNA-binding protein Signal transduction Synaptic plasticity Transcription factors
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