Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK

Ceramide is a sphingolipid that activates stress kinases such as p38 and c-JUN N-Terminal Kinase (JNK). Though Chronic Myelogenous Leukemia (CML) derived K562 cells resist killing by short chain C2-ceramide, we report here that longer chain C6-ceramide promotes apoptosis in these cells. C6-ceramide...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 7; no. 21; pp. 3362 - 3370
Main Authors:	Nica, Alina Felicia, Tsao, Chun Chui, Watt, Julie C., Jiffar, Tilahun, Kurinna, Svitlana, Jurasz, Paul, Konopleva, Marina, Andreeff, Michael, Radomski, Marek W., Ruvolo, Peter P.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01-11-2008
Subjects:	Apoptosis - drug effects Benzamides Binding Biology Bioscience Calcium Cancer Caspase 8 - metabolism Cell Ceramides - pharmacology Cycle Drug Resistance, Neoplasm - drug effects Enzyme Activation - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Fusion Proteins, bcr-abl - metabolism Humans Imatinib Mesylate JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism K562 Cells Landes Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Myeloid Cell Leukemia Sequence 1 Protein Organogenesis p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Piperazines - pharmacology Protein Kinase Inhibitors - pharmacology Protein Phosphatase 2 - metabolism Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrimidines - pharmacology
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