Gender Matters: Nonlinear Relationships Between Heart Rate Variability and Depression and Positive Affect

• Published in: Frontiers in neuroscience Vol. 15; p. 612566
• Main Authors: Spangler, Derek P., Dunn, Emily J., Aldao, Amelia, Feeling, Nicole R., Free, Matthew L., Gillie, Brandon L., Vasey, Michael W., Williams, DeWayne P., Koenig, Julian, Thayer, Julian F.
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 13-05-2021; Frontiers Media S.A
• Subjects: depression; emotion; Emotions; Fainting; Females; Gender; Gender differences; Heart rate; heart rate variability; Mental depression; Nervous system; Neuroscience; nonlinear; Parasympathetic nervous system; positive affect; Sex differences; Social research
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2021.612566

Vagally mediated heart rate variability (vmHRV), a measure of the parasympathetic nervous system’s control over the heart, is often negatively related to maladaptive emotional outcomes. Recent work suggests that quadratic relationships involving these factors may be present; however, research has not investigated gender differences in these nonlinear functions. To address this gap, the current study tested for quadratic relationships between resting vmHRV and depression and positive affect while investigating gender differences in these relationships. Significant quadratic effects were found between resting vmHRV and reports of both depression symptoms and positive affect in women but not men. Specifically, the lowest levels of depression and the highest levels of positive affect were found at moderate vmHRV in women. These results suggest that examinations of vmHRV’s nonlinear associations require the consideration of gender. Our findings are interpreted based on proposed differential neuropsychological mechanisms of vmHRV in men versus women.