In-hospital recurrence and functional outcome between ischemic stroke caused by intracranial arterial dissection and intracranial atherosclerosis: Retrospective cohort study of the nationwide multicenter registry

• Published in: Journal of stroke and cerebrovascular diseases Vol. 32; no. 8; p. 107212
• Main Authors: Fujiwara, Gaku, Oka, Hideki, Fujii, Akihiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-08-2023
• Subjects: Adult; Aortic Dissection - complications; Aortic Dissection - diagnostic imaging; Aortic Dissection - therapy; Cohort Studies; Cohort study; Dissection, Blood Vessel; Epidemiology; Functional outcome; Hospitals; Humans; In-hospital recurrence; Intracranial arterial dissection; Intracranial Arteriosclerosis - complications; Intracranial Arteriosclerosis - diagnostic imaging; Intracranial Arteriosclerosis - epidemiology; Intracranial atherosclerotic stenosis; Ischemic stroke; Ischemic Stroke - diagnostic imaging; Ischemic Stroke - therapy; Registries; Retrospective Studies; Risk Factors; Stroke - diagnostic imaging; Stroke - therapy; Cohort study; Intracranial arterial dissection; Ischemic stroke; In-hospital recurrence; Epidemiology; Intracranial atherosclerotic stenosis; Functional outcome
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2023.107212

Intracranial arterial dissection (ICAD) and intracranial atherosclerotic stenosis (ICAS) are often difficult to differentiate, and studies on their background factors and prognosis are scarce. Information on prognosis, including recurrence, is necessary for stroke care, and clarification of epidemiological and clinical differences between the two diseases is important for appropriately handling their heterogeneity. This study aimed to determine the association of ICAD and ICAS with in-hospital recurrence and prognosis and compare their background and clinical findings.
In this multicenter cohort study, we retrospectively analyzed data from the Saiseikai Stroke Database. Adults with ischemic stroke caused by ICAD or ICAS were included in this study. Patients’ backgrounds and clinical findings were compared between the ICAD and ICAS groups. The outcome showed an association of ICAD with in-hospital recurrence of ischemic stroke and poor functional outcome relative to ICAS. Multivariable logistic regression analyses were performed to calculate the adjusted odds ratios (ORs) for ICAD with 95% confidence intervals (CIs) for each outcome.
Among 15,622 patients registered in the Saiseikai Stroke Database, 2,020 were enrolled (ICAD group: 89; ICAS group: 1,931). In the ICAD group, 65.2% of the patients were aged <64 years. Vascular lesion location was more common in ICAD with the vertebral artery [42 (47.2%)], anterior cerebral artery [20 (22.5%)], and middle cerebral artery (MCA) [16 (18.0%)], and in ICAS with MCA 1046 (52.3%). Multivariable logistic regression analyses of the association between ICAD and in-hospital recurrence and poor functional outcome yielded a crude OR (95% CI) of 3.26 (1.06−9.97) and 0.97 (0.54−1.74), respectively, relative to ICAS.
ICAD was associated with a higher in-hospital recurrence than ICAS; however, there was no significant difference in prognosis between the two groups. Differences in background characteristics and vessel lesions may be of interest in these two diseases.