The Potential of Lamiaceae Herbs for Mitigation of Overweight, Obesity, and Fatty Liver: Studies and Perspectives

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 15; p. 5043
• Main Authors: Diab, Farah, Zbeeb, Hawraa, Baldini, Francesca, Portincasa, Piero, Khalil, Mohamad, Vergani, Laura
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 08-08-2022; MDPI
• Subjects: Alternations; Antioxidants; Body weight; Cardiovascular diseases; Clinical trials; Diabetes; Diabetes mellitus; Fatty liver; Flavonoids; Flowers & plants; Functional foods & nutraceuticals; Herbal medicine; Herbs; Hypotheses; Insulin; Insulin resistance; Lamiaceae; Liver; Liver diseases; Medicinal plants; Metabolic disorders; non-alcoholic fatty liver disease (NAFLD); nutraceutics; Obesity; Overweight; phytochemicals; Plant extracts; Plants; Review; Spices; Therapeutic targets; Weight control
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27155043

Numerous plants, plant extracts, and plant-derived compounds are being explored for their beneficial effects against overweight and liver diseases. Obesity is associated with the increased prevalence of non-alcoholic fatty liver disease (NAFLD), becoming the most common liver disease in Western countries. Obesity and NAFLD are closely associated with many other metabolic alternations such as insulin resistance, diabetes mellitus, and cardiovascular diseases. Many herbs of the Lamiaceae family are widely employed as food and spices in the Mediterranean area, but also in folk medicine, and their use for the management of metabolic disorders is well documented. Hereby, we summarized the scientific results of the medicinal and nutraceutical potential of plants from the Lamiaceae family for prevention and mitigation of overweight and fatty liver. The evidence indicates that Lamiaceae plants may be a cost-effective source of nutraceuticals and/or phytochemicals to be used in the management of metabolic-related conditions such as obesity and NAFLD. PubMed, Google Scholar, Scopus, and SciFinder were accessed to collect data on traditional medicinal plants, compounds derived from plants, their reported anti-obesity mechanisms, and therapeutic targets.