Correlation between salivary epidermal growth factor levels and refractory intraoral manifestations in patients with Sjögren's syndrome

• Published in: Modern rheumatology Vol. 24; no. 4; pp. 626 - 632
• Main Authors: Azuma, Naoto, Katada, Yoshinori, Kitano, Sachie, Sekiguchi, Masahiro, Kitano, Masayasu, Nishioka, Aki, Hashimoto, Naoaki, Matsui, Kiyoshi, Iwasaki, Tsuyoshi, Sano, Hajime
• Format: Journal Article
• Language: English
• Published: United States Informa Healthcare 01-07-2014; Taylor & Francis
• Subjects: Adult; Aged; Aged, 80 and over; Body fluids; Epidermal growth factor; Epidermal Growth Factor - analysis; Female; Humans; Intraoral manifestation; Male; Medical disorders; Middle Aged; Oral mucosal involvement; Rheumatology; Saliva; Saliva - chemistry; Salivation - physiology; Severity of Illness Index; Sjogren's Syndrome - diagnosis; Sjogren's Syndrome - physiopathology; Sjögren's syndrome; Epidermal growth factor; Sjögren's syndrome; Saliva; Intraoral manifestation; Oral mucosal involvement
• ISSN: 1439-7595; 1439-7609
• DOI: 10.3109/14397595.2013.850766

Abstract
Objective. To assess changes in salivary epidermal growth factor (EGF) levels and the correlation between these levels and the severity of intraoral manifestations in Sjögren's syndrome (SS).
Methods. Forty SS patients and 23 controls were enrolled. Salivary EGF concentration was measured using an enzyme-linked immunosorbent assay, and intraoral manifestations were evaluated using a short version of the Oral Health Impact Profile (OHIP-14). The associations among salivary flow rate, EGF levels and the severity of intraoral manifestations were analyzed.
Results. The total salivary EGF output was significantly decreased in the SS patients compared with the controls (9237.6 ± 8447.0 vs. 13296.9 ± 7907.1 pg/10 min, respectively, p = 0.033). In the SS patients, total EGF output and salivary flow rate showed a strong positive correlation (rs = 0.824, p = 0.0005), while total EGF output and disease duration showed a negative correlation (rs = −0.484, p = 0.008). Further, total EGF output was significantly correlated with the OHIP-14 score (rs = −0.721, p = 0.012).
Conclusions. The salivary flow rate and EGF levels are decreased in SS, and this deterioration in saliva quality causes refractory intraoral manifestations. Our findings have provided new therapeutic targets for SS.